Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer's disease and three sex- and age-matched healthy controls

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075129" target="_blank" >RIV/00159816:_____/21:00075129 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/21:00120174

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1873506121002245?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1873506121002245?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scr.2021.102378" target="_blank" >10.1016/j.scr.2021.102378</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer's disease and three sex- and age-matched healthy controls

Popis výsledku v původním jazyce

Human induced pluripotent stem cell (iPSC) lines were generated from patients with spontaneous late-onset Alzheimer&apos;s disease (AD) and three healthy control individuals. Peripheral blood mononuclear cells were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer&apos;s disease in vitro.

Název v anglickém jazyce

Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer's disease and three sex- and age-matched healthy controls

Popis výsledku anglicky

Human induced pluripotent stem cell (iPSC) lines were generated from patients with spontaneous late-onset Alzheimer&apos;s disease (AD) and three healthy control individuals. Peripheral blood mononuclear cells were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer&apos;s disease in vitro.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/NV19-08-00472" target="_blank" >NV19-08-00472: Klinicky relevantní biochemické, imunologické a buněčné biomarkery Alzheimerovy nemoci a stárnutí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stem Cell Research

ISSN

1873-5061

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

—

Kód UT WoS článku

000656247000002

EID výsledku v databázi Scopus

—