Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076331" target="_blank" >RIV/00159816:_____/22:00076331 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/22:10443165 RIV/00216208:11110/22:10443165 RIV/00216224:14110/22:00125641

Výsledek na webu

<a href="https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3" target="_blank" >https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12903-022-02115-3" target="_blank" >10.1186/s12903-022-02115-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

Popis výsledku v původním jazyce

Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr &gt; 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P &lt; 0.035, P-corr &gt; 0.05, respectively) than in men with RAS (P &gt; 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr &lt; 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P &lt; 0.00001) and CGI haplotype was less frequent in RAS patients (P &lt; 0.01), especially in women (P = 0.016, P-corr &gt; 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

Název v anglickém jazyce

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

Popis výsledku anglicky

Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr &gt; 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P &lt; 0.035, P-corr &gt; 0.05, respectively) than in men with RAS (P &gt; 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr &lt; 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P &lt; 0.00001) and CGI haplotype was less frequent in RAS patients (P &lt; 0.01), especially in women (P = 0.016, P-corr &gt; 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Oral Health

ISSN

1472-6831

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

80

Kód UT WoS článku

000770760100002

EID výsledku v databázi Scopus

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