Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076638" target="_blank" >RIV/00159816:_____/22:00076638 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/22:00129377

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1388245722008872?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1388245722008872?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2022.09.002" target="_blank" >10.1016/j.clinph.2022.09.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy

Popis výsledku v původním jazyce

Objective: To review the therapeutic effects of deep brain stimulation of the anterior nuclei of the thala-mus (ANT-DBS) and the predictors of its effectiveness, safety, and adverse effects. Methods: A comprehensive search of the medical literature (PubMed) was conducted to identify relevant articles investigating ANT-DBS therapy for epilepsy. Out of 332 references, 77 focused on focal epilepsies were reviewed. Results: The DBS effect is probably due to decreased synchronization of epileptic activity in the cortex. The potential mechanisms from cellular to brain network levels are presented. The ANT might participate actively in the network elaborating focal seizures. The effects of ANT-DBS differed in various studies; ANT-DBS was linked with a 41% seizure frequency reduction at 1 year, 69% at 5 years, and 75% at 7 years. The most frequently reported adverse effects, depression and memory impairment, were considered non -serious in the long-term follow-up view. ANT-DBS also has been used in a few cases to treat status epilep-ticus. Conclusions: We reviewed the clinical literature and identified several factors that may predict seizure outcome following DBS therapy. More large-scale trials are required since there is a need to explore stim-ulation settings, apply patient-tailored therapy, and identify the presurgical predictors of patient response. Significance: A critical review of the published literature on ANT-DBS in focal epilepsy is presented. ANT-DBS mechanisms are not fully understood; possible explanations are provided. Biomarkers of ANT-DBS effectiveness may lead to patient-tailored therapy. (c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy

Popis výsledku anglicky

Objective: To review the therapeutic effects of deep brain stimulation of the anterior nuclei of the thala-mus (ANT-DBS) and the predictors of its effectiveness, safety, and adverse effects. Methods: A comprehensive search of the medical literature (PubMed) was conducted to identify relevant articles investigating ANT-DBS therapy for epilepsy. Out of 332 references, 77 focused on focal epilepsies were reviewed. Results: The DBS effect is probably due to decreased synchronization of epileptic activity in the cortex. The potential mechanisms from cellular to brain network levels are presented. The ANT might participate actively in the network elaborating focal seizures. The effects of ANT-DBS differed in various studies; ANT-DBS was linked with a 41% seizure frequency reduction at 1 year, 69% at 5 years, and 75% at 7 years. The most frequently reported adverse effects, depression and memory impairment, were considered non -serious in the long-term follow-up view. ANT-DBS also has been used in a few cases to treat status epilep-ticus. Conclusions: We reviewed the clinical literature and identified several factors that may predict seizure outcome following DBS therapy. More large-scale trials are required since there is a need to explore stim-ulation settings, apply patient-tailored therapy, and identify the presurgical predictors of patient response. Significance: A critical review of the published literature on ANT-DBS in focal epilepsy is presented. ANT-DBS mechanisms are not fully understood; possible explanations are provided. Biomarkers of ANT-DBS effectiveness may lead to patient-tailored therapy. (c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA21-25953S" target="_blank" >GA21-25953S: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Svazek periodika

144

Číslo periodika v rámci svazku

DEC 22

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

000886064800001

EID výsledku v databázi Scopus

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