Vagus nerve stimulation outcome prediction: from simple parameters to advanced models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076710" target="_blank" >RIV/00159816:_____/22:00076710 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/22:00129736

Výsledek na webu

<a href="http://www.elis.sk/download_file.php?product_id=7788&session_id=rhdsqlrbjs63gbjmr024us8i14" target="_blank" >http://www.elis.sk/download_file.php?product_id=7788&session_id=rhdsqlrbjs63gbjmr024us8i14</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2022_103" target="_blank" >10.4149/BLL_2022_103</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vagus nerve stimulation outcome prediction: from simple parameters to advanced models

Popis výsledku v původním jazyce

Since its approval as an adjunct treatment for refractory partial epilepsy, the positive effects of vagus nerve stimulation (VNS) on seizure frequency and severity have been supported by many studies. Seizure reduction of more than 50 % can be expected in at least 50 % of patients. However, a complete post-VNS seizure freedom is rarely achieved and 25 % of patients do not benefi t from VNS. Our study provides an overview of the potential predictors of VNS response, from the most simple and basic data to sophisticated EEG processing studies and functional imaging studying brain connectivity. The data support better outcomes in younger patients with early VNS implantation, in patients with posttraumatic epilepsy or tuberous sclerosis, and in patients without bilateral interictal epileptiform discharges. The variability of heart activity has also been studied with some promising results. Because the generally accepted hypothesis of the VNS mechanism is the modulation of synaptic activity in multiple cortical and subcortical regions of the brain, the studies of brain response to external stimulation and/or of brain connectivity were used for models predicting the effect of VNS in individual patients. Although the predictive value of these models is high, the required special equipment and sophisticated mathematical tools limit their routine use (C) 2022. Bratislava Medical Journal. All Rights Reserved.

Název v anglickém jazyce

Vagus nerve stimulation outcome prediction: from simple parameters to advanced models

Popis výsledku anglicky

Since its approval as an adjunct treatment for refractory partial epilepsy, the positive effects of vagus nerve stimulation (VNS) on seizure frequency and severity have been supported by many studies. Seizure reduction of more than 50 % can be expected in at least 50 % of patients. However, a complete post-VNS seizure freedom is rarely achieved and 25 % of patients do not benefi t from VNS. Our study provides an overview of the potential predictors of VNS response, from the most simple and basic data to sophisticated EEG processing studies and functional imaging studying brain connectivity. The data support better outcomes in younger patients with early VNS implantation, in patients with posttraumatic epilepsy or tuberous sclerosis, and in patients without bilateral interictal epileptiform discharges. The variability of heart activity has also been studied with some promising results. Because the generally accepted hypothesis of the VNS mechanism is the modulation of synaptic activity in multiple cortical and subcortical regions of the brain, the studies of brain response to external stimulation and/or of brain connectivity were used for models predicting the effect of VNS in individual patients. Although the predictive value of these models is high, the required special equipment and sophisticated mathematical tools limit their routine use (C) 2022. Bratislava Medical Journal. All Rights Reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30200 - Clinical medicine

Projekt

<a href="/cs/project/NV19-04-00343" target="_blank" >NV19-04-00343: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské Lekárske Listy

ISSN

0006-9248

e-ISSN

—

Svazek periodika

123

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

641-647

Kód UT WoS článku

000903730000006

EID výsledku v databázi Scopus

2-s2.0-85135856094