New insights into the genetic etiology of Alzheimer's disease and related dementias

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077610" target="_blank" >RIV/00159816:_____/22:00077610 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/22:10442870 RIV/00216208:11130/22:10442870

Výsledek na webu

<a href="https://www.nature.com/articles/s41588-022-01024-z" target="_blank" >https://www.nature.com/articles/s41588-022-01024-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41588-022-01024-z" target="_blank" >10.1038/s41588-022-01024-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

New insights into the genetic etiology of Alzheimer's disease and related dementias

Popis výsledku v původním jazyce

Characterization of the genetic landscape of Alzheimer&apos;s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/&apos;proxy&apos; AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE epsilon 4 allele. Meta-analysis of genome-wide association studies on Alzheimer&apos;s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer&apos;s disease and dementia.

Název v anglickém jazyce

New insights into the genetic etiology of Alzheimer's disease and related dementias

Popis výsledku anglicky

Characterization of the genetic landscape of Alzheimer&apos;s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/&apos;proxy&apos; AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE epsilon 4 allele. Meta-analysis of genome-wide association studies on Alzheimer&apos;s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer&apos;s disease and dementia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature genetics

ISSN

1061-4036

e-ISSN

1546-1718

Svazek periodika

54

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

29

Strana od-do

412-"+"

Kód UT WoS článku

000778079600002

EID výsledku v databázi Scopus

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