Pharmacokinetics of colistin during extracorporeal membrane oxygenation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077615" target="_blank" >RIV/00159816:_____/22:00077615 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/22:00127663

Výsledek na webu

<a href="https://academic.oup.com/jac/article-abstract/77/8/2298/6591052?redirectedFrom=fulltext&login=true" target="_blank" >https://academic.oup.com/jac/article-abstract/77/8/2298/6591052?redirectedFrom=fulltext&login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jac/dkac163" target="_blank" >10.1093/jac/dkac163</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacokinetics of colistin during extracorporeal membrane oxygenation

Popis výsledku v původním jazyce

During the recent COVID-19 pandemic, several patients required extracorporeal membrane oxygenation (ECMO) due to COVID-19 infection complicated by ventilator-associated pneumonia caused by MDR Pseudomonas aeruginosa that was only susceptible to colistin.Extracorporeal circuits, in general, represent another compartment that increases the volume of distribution for hydrophilic compounds and may affect drug clearance.1 Besides that, ECMO can, more importantly, influence pharmacokinetics by drug adsorption on the circuit surface. This phenomenon is influenced by physicochemical properties of the medication - mainly lipophilicity and protein binding - but it is also dependent on particular materials of circuit components and circuit coating. Since both colistin and its prodrug colistin methanesulfonate (CMS) are hydrophilic substances (logP MINUS SIGN 2.4 for colistin) with medium protein binding (approx. 50% for colistin), adsorption on the ECMO circuit seems unlikely. We have not found any data on potential adsorption on an ECMO circuit; however, adsorption on the polysulphone membrane dialyser was described.2 Therefore, we were concerned about the reduced plasma levels and disturbed effectiveness of colistin therapy in our patients.

Název v anglickém jazyce

Pharmacokinetics of colistin during extracorporeal membrane oxygenation

Popis výsledku anglicky

During the recent COVID-19 pandemic, several patients required extracorporeal membrane oxygenation (ECMO) due to COVID-19 infection complicated by ventilator-associated pneumonia caused by MDR Pseudomonas aeruginosa that was only susceptible to colistin.Extracorporeal circuits, in general, represent another compartment that increases the volume of distribution for hydrophilic compounds and may affect drug clearance.1 Besides that, ECMO can, more importantly, influence pharmacokinetics by drug adsorption on the circuit surface. This phenomenon is influenced by physicochemical properties of the medication - mainly lipophilicity and protein binding - but it is also dependent on particular materials of circuit components and circuit coating. Since both colistin and its prodrug colistin methanesulfonate (CMS) are hydrophilic substances (logP MINUS SIGN 2.4 for colistin) with medium protein binding (approx. 50% for colistin), adsorption on the ECMO circuit seems unlikely. We have not found any data on potential adsorption on an ECMO circuit; however, adsorption on the polysulphone membrane dialyser was described.2 Therefore, we were concerned about the reduced plasma levels and disturbed effectiveness of colistin therapy in our patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of antimicrobial chemotherapy

ISSN

0305-7453

e-ISSN

1460-2091

Svazek periodika

77

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

2298-2300

Kód UT WoS článku

000799265500001

EID výsledku v databázi Scopus

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