Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00077840" target="_blank" >RIV/00159816:_____/23:00077840 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00130206

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.18770" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.18770</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jdv.18770" target="_blank" >10.1111/jdv.18770</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

Popis výsledku v původním jazyce

BackgroundChronic venous disease (CVD) is a common disorder of lower extremities. ObjectivesThe study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF alpha (-238 A/G; -308 A/G), TNF beta (NcoI), IL-1 beta (+3953 T/C); IL-6 (-174 G/C; -596 G/C) and ADAM17 (3 &apos; TACE) and CVD risk. Genotype-phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD. MethodsFinally, 150 CVD patients and 227 control subjects were enrolled to the study.Genotypes in proinflammatory gene polymorphisms were identified from isolated DNA by PCR method and restriction analysis. ResultsSignificant differences in genotype distribution/allelic frequencies in TNF beta gene, IL-1 beta gene and in ADAM17 gene polymorphisms were found between CVD women and control ones. In the genotype-phenotype study, identified genotypes were associated with arterial hypertension (ADAM17, IL-6-men), ischaemic heart disease (TNF alpha and beta genes), diabetes mellitus (ADAM17-women, TNF beta-men), age of CVD onset (TNF alpha and IL-6), ulceration (ADAM17), duration of ulceration (ADAM17), ulceration recurrence (ADAM17-women), home care necessity (TNF alpha), varices surgery (TNF alpha), erysipelas development (ADAM17-men) and tumour development (TNF alpha). ConclusionStudying of these polymorphisms associations can help us better identify patients at higher risk of developing severe CVD.

Název v anglickém jazyce

Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

Popis výsledku anglicky

BackgroundChronic venous disease (CVD) is a common disorder of lower extremities. ObjectivesThe study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF alpha (-238 A/G; -308 A/G), TNF beta (NcoI), IL-1 beta (+3953 T/C); IL-6 (-174 G/C; -596 G/C) and ADAM17 (3 &apos; TACE) and CVD risk. Genotype-phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD. MethodsFinally, 150 CVD patients and 227 control subjects were enrolled to the study.Genotypes in proinflammatory gene polymorphisms were identified from isolated DNA by PCR method and restriction analysis. ResultsSignificant differences in genotype distribution/allelic frequencies in TNF beta gene, IL-1 beta gene and in ADAM17 gene polymorphisms were found between CVD women and control ones. In the genotype-phenotype study, identified genotypes were associated with arterial hypertension (ADAM17, IL-6-men), ischaemic heart disease (TNF alpha and beta genes), diabetes mellitus (ADAM17-women, TNF beta-men), age of CVD onset (TNF alpha and IL-6), ulceration (ADAM17), duration of ulceration (ADAM17), ulceration recurrence (ADAM17-women), home care necessity (TNF alpha), varices surgery (TNF alpha), erysipelas development (ADAM17-men) and tumour development (TNF alpha). ConclusionStudying of these polymorphisms associations can help us better identify patients at higher risk of developing severe CVD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30216 - Dermatology and venereal diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of European Academy of Dermatology Venereology

ISSN

0926-9959

e-ISSN

1468-3083

Svazek periodika

37

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

590-597

Kód UT WoS článku

000897650900001

EID výsledku v databázi Scopus

2-s2.0-85143540501