Birth outcomes, puberty onset, and obesity as long-term predictors of biological aging in young adulthood

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00077885" target="_blank" >RIV/00159816:_____/23:00077885 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/23:00130447 RIV/65269705:_____/23:00077885

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fnut.2022.1100237/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnut.2022.1100237/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnut.2022.1100237" target="_blank" >10.3389/fnut.2022.1100237</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Birth outcomes, puberty onset, and obesity as long-term predictors of biological aging in young adulthood

Popis výsledku v původním jazyce

BackgroundBiological aging and particularly the deviations between biological and chronological age are better predictors of health than chronological age alone. However, the predictors of accelerated biological aging are not very well understood. The aim was to determine the role of birth outcomes, time of puberty onset, body mass index (BMI), and body fat in accelerated biological aging in the third decade of life. MethodsWe have conducted a second follow-up of the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) prenatal birth cohort in young adulthood (52% male; age 28-30; n = 262) to determine the role of birth outcomes, pubertal timing, BMI, and body fat on biological aging. Birth outcomes included birth weight, length, and gestational age at birth. Pubertal timing was determined by the presence of secondary sexual characteristics at the age of 11 and the age of first menarche in women. Biological age was estimated using the Klemera-Doubal Method (KDM), which applies 9-biomarker algorithm including forced expiratory volume in one second (FEV1), systolic blood pressure, glycated hemoglobin, total cholesterol, C-reactive protein, creatinine, urea nitrogen, albumin, and alkaline phosphatase. Accelerated/decelerated aging was determined as the difference between biological and chronological age (BioAGE). ResultsThe deviations between biological and chronological age in young adulthood ranged from -2.84 to 4.39 years. Accelerated biological aging was predicted by higher BMI [in both early (R-adj(2) = 0.05) and late 20s (R-adj(2) = 0.22)], subcutaneous (R-adj(2) = 0.21) and visceral fat (R-adj(2) = 0.25), puberty onset (eta(2)(p) = 0.07), birth length (R-adj(2) = 0.03), and the increase of BMI over the 5-year period between the two follow-ups in young adulthood (R-adj(2) = 0.09). Single hierarchical model revealed that shorter birth length, early puberty onset, and greater levels of visceral fat were the main predictors, together explaining 21% of variance in accelerated biological aging. ConclusionOur findings provide comprehensive support of the Life History Theory, suggesting that early life adversity might trigger accelerated aging, which leads to earlier onset of puberty but decreasing fitness in adulthood, reflected by more visceral fat and higher BMI. Our findings also suggest that reduction of BMI in young adulthood slows down biological aging.

Název v anglickém jazyce

Birth outcomes, puberty onset, and obesity as long-term predictors of biological aging in young adulthood

Popis výsledku anglicky

BackgroundBiological aging and particularly the deviations between biological and chronological age are better predictors of health than chronological age alone. However, the predictors of accelerated biological aging are not very well understood. The aim was to determine the role of birth outcomes, time of puberty onset, body mass index (BMI), and body fat in accelerated biological aging in the third decade of life. MethodsWe have conducted a second follow-up of the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) prenatal birth cohort in young adulthood (52% male; age 28-30; n = 262) to determine the role of birth outcomes, pubertal timing, BMI, and body fat on biological aging. Birth outcomes included birth weight, length, and gestational age at birth. Pubertal timing was determined by the presence of secondary sexual characteristics at the age of 11 and the age of first menarche in women. Biological age was estimated using the Klemera-Doubal Method (KDM), which applies 9-biomarker algorithm including forced expiratory volume in one second (FEV1), systolic blood pressure, glycated hemoglobin, total cholesterol, C-reactive protein, creatinine, urea nitrogen, albumin, and alkaline phosphatase. Accelerated/decelerated aging was determined as the difference between biological and chronological age (BioAGE). ResultsThe deviations between biological and chronological age in young adulthood ranged from -2.84 to 4.39 years. Accelerated biological aging was predicted by higher BMI [in both early (R-adj(2) = 0.05) and late 20s (R-adj(2) = 0.22)], subcutaneous (R-adj(2) = 0.21) and visceral fat (R-adj(2) = 0.25), puberty onset (eta(2)(p) = 0.07), birth length (R-adj(2) = 0.03), and the increase of BMI over the 5-year period between the two follow-ups in young adulthood (R-adj(2) = 0.09). Single hierarchical model revealed that shorter birth length, early puberty onset, and greater levels of visceral fat were the main predictors, together explaining 21% of variance in accelerated biological aging. ConclusionOur findings provide comprehensive support of the Life History Theory, suggesting that early life adversity might trigger accelerated aging, which leads to earlier onset of puberty but decreasing fitness in adulthood, reflected by more visceral fat and higher BMI. Our findings also suggest that reduction of BMI in young adulthood slows down biological aging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

—

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Nutrition

ISSN

2296-861X

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

JAN 10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

1100237

Kód UT WoS článku

000919818000001

EID výsledku v databázi Scopus

2-s2.0-85147036421