Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078707" target="_blank" >RIV/00159816:_____/23:00078707 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00134627

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0009912022002715?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0009912022002715?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2022.12.002" target="_blank" >10.1016/j.clinbiochem.2022.12.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

Popis výsledku v původním jazyce

Objectives: Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely. In this study the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) are described and the predictive value of these markers for the early diagnosis of acute intestinal ischemia is assessed.Design &amp; methods: This non-randomised, single-centre cohort study enrolled 50 patients with abdominal aortic aneurysm (AAA) and 30 patients with aortoiliac occlusive disease (AOID). Serum D-lactate and IMA were assessed pre-, intra-, and postoperatively at eight defined time points.Results: The highest serum D-lactate was at 6 h after complete declamping of the vascular graft. The highest predictive power of D-lactate was at 3 h after complete declamping (AUC 0.857). IMA was found to be higher in the AAA group in ischemic patients 10 min after complete declamping than in the AOID group. The highest predictive values of IMA were at 1 h after aortic cross-clamping (AUC 0.758) and 3 and 6 h after complete declamping (0.745 and 0.721, respectively). Moreover, the multivariate model with both markers at 3 h after complete declamping improved the detection of intestinal ischemia (AUC 0.894).Conclusions: Serum levels of IMA and D-lactate seem to be influential predictive markers for postoperative intestinal ischemia, especially after 3 h from complete declamping of vascular reconstruction.

Název v anglickém jazyce

Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

Popis výsledku anglicky

Objectives: Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely. In this study the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) are described and the predictive value of these markers for the early diagnosis of acute intestinal ischemia is assessed.Design &amp; methods: This non-randomised, single-centre cohort study enrolled 50 patients with abdominal aortic aneurysm (AAA) and 30 patients with aortoiliac occlusive disease (AOID). Serum D-lactate and IMA were assessed pre-, intra-, and postoperatively at eight defined time points.Results: The highest serum D-lactate was at 6 h after complete declamping of the vascular graft. The highest predictive power of D-lactate was at 3 h after complete declamping (AUC 0.857). IMA was found to be higher in the AAA group in ischemic patients 10 min after complete declamping than in the AOID group. The highest predictive values of IMA were at 1 h after aortic cross-clamping (AUC 0.758) and 3 and 6 h after complete declamping (0.745 and 0.721, respectively). Moreover, the multivariate model with both markers at 3 h after complete declamping improved the detection of intestinal ischemia (AUC 0.894).Conclusions: Serum levels of IMA and D-lactate seem to be influential predictive markers for postoperative intestinal ischemia, especially after 3 h from complete declamping of vascular reconstruction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30200 - Clinical medicine

Projekt

<a href="/cs/project/NV17-29701A" target="_blank" >NV17-29701A: Ischémií modifikovaný albumin a cirkulující mikroRNA jako nové technologie k monitorování tkáňové ischémie po cévních rekonstrukcích na břišní aortě</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

1873-2933

Svazek periodika

112

Číslo periodika v rámci svazku

FEB 2023

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

43-47

Kód UT WoS článku

000923758200001

EID výsledku v databázi Scopus

2-s2.0-85144808793