Endemic parkinsonism: clusters, biology and clinical features

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079481" target="_blank" >RIV/00159816:_____/23:00079481 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00132289 RIV/00216208:11120/23:43926016 RIV/00064173:_____/23:43926016 RIV/00098892:_____/23:10158031 a 2 dalších

Výsledek na webu

<a href="https://www.nature.com/articles/s41582-023-00866-3" target="_blank" >https://www.nature.com/articles/s41582-023-00866-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41582-023-00866-3" target="_blank" >10.1038/s41582-023-00866-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endemic parkinsonism: clusters, biology and clinical features

Popis výsledku v původním jazyce

The term &apos;endemic parkinsonism&apos; refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are present only in a particular geographically defined location or population. Ten phenotypes of endemic parkinsonism are currently known: three in the Western Pacific region; two in the Asian-Oceanic region; one in the Caribbean islands of Guadeloupe and Martinique; and four in Europe. Some of these disease entities seem to be disappearing over time and therefore are probably triggered by unique environmental factors. By contrast, other types persist because they are exclusively genetically determined. Given the geographical clustering and potential overlap in biological and clinical features of these exceptionally interesting diseases, this Review provides a historical reference text and offers current perspectives on each of the 10 phenotypes of endemic parkinsonism. Knowledge obtained from the study of these disease entities supports the hypothesis that both genetic and environmental factors contribute to the development of neurodegenerative diseases, not only in endemic parkinsonism but also in general. At the same time, this understanding suggests useful directions for further research in this area. Endemic parkinsonism occurs only in specific locations or populations. Here, Mensikova et al. describe clusters of endemic parkinsonism and highlight that those linked to neurotoxic environmental factors seem to be disappearing, while genetically determined clusters persist. Existing definitions and classification schemes for endemic parkinsonism all have limitations.Foci of endemic parkinsonism are clustered by geographic region as well as clinical features.Endemic parkinsonism has a highly heterogeneous pathological background.Some clusters of endemic parkinsonism are associated with exposure to neurotoxic environmental factors.Other clusters of endemic parkinsonism have a primarily genetic cause.Further study of endemic parkinsonism could illuminate future research into neurodegenerative diseases.

Název v anglickém jazyce

Endemic parkinsonism: clusters, biology and clinical features

Popis výsledku anglicky

The term &apos;endemic parkinsonism&apos; refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are present only in a particular geographically defined location or population. Ten phenotypes of endemic parkinsonism are currently known: three in the Western Pacific region; two in the Asian-Oceanic region; one in the Caribbean islands of Guadeloupe and Martinique; and four in Europe. Some of these disease entities seem to be disappearing over time and therefore are probably triggered by unique environmental factors. By contrast, other types persist because they are exclusively genetically determined. Given the geographical clustering and potential overlap in biological and clinical features of these exceptionally interesting diseases, this Review provides a historical reference text and offers current perspectives on each of the 10 phenotypes of endemic parkinsonism. Knowledge obtained from the study of these disease entities supports the hypothesis that both genetic and environmental factors contribute to the development of neurodegenerative diseases, not only in endemic parkinsonism but also in general. At the same time, this understanding suggests useful directions for further research in this area. Endemic parkinsonism occurs only in specific locations or populations. Here, Mensikova et al. describe clusters of endemic parkinsonism and highlight that those linked to neurotoxic environmental factors seem to be disappearing, while genetically determined clusters persist. Existing definitions and classification schemes for endemic parkinsonism all have limitations.Foci of endemic parkinsonism are clustered by geographic region as well as clinical features.Endemic parkinsonism has a highly heterogeneous pathological background.Some clusters of endemic parkinsonism are associated with exposure to neurotoxic environmental factors.Other clusters of endemic parkinsonism have a primarily genetic cause.Further study of endemic parkinsonism could illuminate future research into neurodegenerative diseases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Reviews Neurology

ISSN

1759-4758

e-ISSN

1759-4766

Svazek periodika

19

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

599-616

Kód UT WoS článku

001061908600001

EID výsledku v databázi Scopus

—