The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079634" target="_blank" >RIV/00159816:_____/23:00079634 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/24:00558938 RIV/00216208:11130/23:10453116 RIV/00216208:11150/23:10453116 RIV/00179906:_____/23:10453116 RIV/00064203:_____/23:10453116

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0753332223000112?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0753332223000112?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2023.114223" target="_blank" >10.1016/j.biopha.2023.114223</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease

Popis výsledku v původním jazyce

Background: The acetylcholinesterase inhibitor donepezil is administered as a treatment for Alzheimer&apos;s disease (AD). However, the appropriate donepezil dosage is still a matter of debate. Methods: Forty AD patients receiving 10 mg/day of donepezil were randomly divided into four groups based on the time of plasma and cerebrospinal fluid (CSF) sampling: 6 h (n = 5), 12 h (n = 12), 18 h (n = 6) and 24 h (n = 17) after donepezil administration. High-performance liquid chromatography measured the donepezil concentration in plasma samples and CSF samples collected at 4-time points. Results: Plasma and CSF levels among the groups were not significantly different. Conversely, the CSF/plasma donepezil concentration ratio considerably increased in the 24 h group compared to the 6 h (p &lt; 0.005) and 12 h (p &lt; 0.05) groups. Conclusion: The measurement of the CSF/plasma donepezil concentration ratio could be used to better evaluate the optimal dose of donepezil.

Název v anglickém jazyce

The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease

Popis výsledku anglicky

Background: The acetylcholinesterase inhibitor donepezil is administered as a treatment for Alzheimer&apos;s disease (AD). However, the appropriate donepezil dosage is still a matter of debate. Methods: Forty AD patients receiving 10 mg/day of donepezil were randomly divided into four groups based on the time of plasma and cerebrospinal fluid (CSF) sampling: 6 h (n = 5), 12 h (n = 12), 18 h (n = 6) and 24 h (n = 17) after donepezil administration. High-performance liquid chromatography measured the donepezil concentration in plasma samples and CSF samples collected at 4-time points. Results: Plasma and CSF levels among the groups were not significantly different. Conversely, the CSF/plasma donepezil concentration ratio considerably increased in the 24 h group compared to the 6 h (p &lt; 0.005) and 12 h (p &lt; 0.05) groups. Conclusion: The measurement of the CSF/plasma donepezil concentration ratio could be used to better evaluate the optimal dose of donepezil.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicine &amp; Pharmacotherapy

ISSN

0753-3322

e-ISSN

1950-6007

Svazek periodika

159

Číslo periodika v rámci svazku

MAR 2023

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

114223

Kód UT WoS článku

000925261300001

EID výsledku v databázi Scopus

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