Severe sleep apnea as a predictor of failure to respond to cardiac resynchronization therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079644" target="_blank" >RIV/00159816:_____/23:00079644 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0147956323000183?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0147956323000183?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.hrtlng.2023.01.018" target="_blank" >10.1016/j.hrtlng.2023.01.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Severe sleep apnea as a predictor of failure to respond to cardiac resynchronization therapy

Popis výsledku v původním jazyce

Background: The response to cardiac resynchronization therapy (CRT) is suboptimal in one-third of patients. Objectives: The study aimed to evaluate the impact of sleep-disordered breathing (SDB) on the CRT-induced left ventricular (LV) reverse remodeling and response for CRT in patients with ischemic congestive heart fail-ure (CHF).Methods: A total of 37 patients aged 65.43 years (SD 6.05), seven of whom were females, were treated with CRT according to class I European Society of Cardiology recommendations. Clinical evaluation, polysomnog-raphy, and contrast echocardiography were performed twice during the six-month follow-up (6M-FU) to assess the effect of CRT.Results: In 33 patients (89.1%), sleep-disordered breathing (SDB), predominantly central sleep apnea (70.3%) was observed. This include nine patients (24.3%) with an apnea-hypopnea index (AHI) of &gt;30 events/hour. During the 6M-FU, 16 patients (47.1%) responded to CRT by reducing LV end-systolic volume index (LVESVi) by &gt;15%. We stated a directly proportional linear relationship between AHI value and LV volume: LVESVi p = 0.004, and LV end-diastolic volume index p = 0.006.Conclusions: Pre-existing severe SDB can impair the LV volumetric response to CRT even in an optimally selected group with class I indications for resynchronization, which may have an impact on long-term prog-nosis.(c) 2023 Published by Elsevier Inc.

Název v anglickém jazyce

Severe sleep apnea as a predictor of failure to respond to cardiac resynchronization therapy

Popis výsledku anglicky

Background: The response to cardiac resynchronization therapy (CRT) is suboptimal in one-third of patients. Objectives: The study aimed to evaluate the impact of sleep-disordered breathing (SDB) on the CRT-induced left ventricular (LV) reverse remodeling and response for CRT in patients with ischemic congestive heart fail-ure (CHF).Methods: A total of 37 patients aged 65.43 years (SD 6.05), seven of whom were females, were treated with CRT according to class I European Society of Cardiology recommendations. Clinical evaluation, polysomnog-raphy, and contrast echocardiography were performed twice during the six-month follow-up (6M-FU) to assess the effect of CRT.Results: In 33 patients (89.1%), sleep-disordered breathing (SDB), predominantly central sleep apnea (70.3%) was observed. This include nine patients (24.3%) with an apnea-hypopnea index (AHI) of &gt;30 events/hour. During the 6M-FU, 16 patients (47.1%) responded to CRT by reducing LV end-systolic volume index (LVESVi) by &gt;15%. We stated a directly proportional linear relationship between AHI value and LV volume: LVESVi p = 0.004, and LV end-diastolic volume index p = 0.006.Conclusions: Pre-existing severe SDB can impair the LV volumetric response to CRT even in an optimally selected group with class I indications for resynchronization, which may have an impact on long-term prog-nosis.(c) 2023 Published by Elsevier Inc.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart &amp; Lung

ISSN

0147-9563

e-ISSN

1527-3288

Svazek periodika

59

Číslo periodika v rámci svazku

MAY 2023

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

102-108

Kód UT WoS článku

000942538300001

EID výsledku v databázi Scopus

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