Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079779" target="_blank" >RIV/00159816:_____/23:00079779 - isvavai.cz</a>
Výsledek na webu
<a href="https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12557" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12557</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/alz.12557" target="_blank" >10.1002/alz.12557</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging
Popis výsledku v původním jazyce
Introduction We examined the association between cerebrospinal fluid (CSF)-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non-demented adults. Methods We included 784 persons (699 cognitively unimpaired, 85 with mild cognitive impairment) aged >= 50 years who underwent CSF amyloid beta (A beta 42), hyperphosphorylated tau 181 (p-tau), and total tau (t-tau) as well as NPS assessment using Beck Depression and Anxiety Inventories (BDI-II, BAI), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Lower CSF A beta 42, and higher t-tau/A beta 42 and p-tau/A beta 42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II >= 13), and clinical anxiety (BAI >= 10), as well as NPI-Q-assessed anxiety, apathy, and nighttime behavior. Discussion CSF A beta 42, t-tau/A beta 42, and p-tau/A beta 42 ratios were associated with NPS in community-dwelling individuals free of dementia. If confirmed by a longitudinal cohort study, the findings have clinical relevance of taking into account the NPS status of individuals with abnormal CSF biomarkers.
Název v anglickém jazyce
Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging
Popis výsledku anglicky
Introduction We examined the association between cerebrospinal fluid (CSF)-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non-demented adults. Methods We included 784 persons (699 cognitively unimpaired, 85 with mild cognitive impairment) aged >= 50 years who underwent CSF amyloid beta (A beta 42), hyperphosphorylated tau 181 (p-tau), and total tau (t-tau) as well as NPS assessment using Beck Depression and Anxiety Inventories (BDI-II, BAI), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Results Lower CSF A beta 42, and higher t-tau/A beta 42 and p-tau/A beta 42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II >= 13), and clinical anxiety (BAI >= 10), as well as NPI-Q-assessed anxiety, apathy, and nighttime behavior. Discussion CSF A beta 42, t-tau/A beta 42, and p-tau/A beta 42 ratios were associated with NPS in community-dwelling individuals free of dementia. If confirmed by a longitudinal cohort study, the findings have clinical relevance of taking into account the NPS status of individuals with abnormal CSF biomarkers.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30210 - Clinical neurology
Návaznosti výsledku
Projekt
<a href="/cs/project/LQ1605" target="_blank" >LQ1605: Translační medicína</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Alzheimers & Dementia
ISSN
1552-5260
e-ISSN
1552-5279
Svazek periodika
19
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
4498-4506
Kód UT WoS článku
000753476600001
EID výsledku v databázi Scopus
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