Parkinsons disease cardiovascular symptoms: A new complex functional and structural insight

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00079738" target="_blank" >RIV/00159816:_____/24:00079738 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00139925

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ene.16110" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ene.16110</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.16110" target="_blank" >10.1111/ene.16110</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Parkinsons disease cardiovascular symptoms: A new complex functional and structural insight

Popis výsledku v původním jazyce

Background: The known impairments of the cardiovascular system in Parkinson&apos;s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research.Objectives: To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients.Methods: Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR).Results: PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p &lt; 0.01), peak SBP (155.8 vs. 170.8 mmHg, p &lt; 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p &lt; 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m(2), respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m(2), p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found.Conclusions: This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.

Název v anglickém jazyce

Parkinsons disease cardiovascular symptoms: A new complex functional and structural insight

Popis výsledku anglicky

Background: The known impairments of the cardiovascular system in Parkinson&apos;s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research.Objectives: To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients.Methods: Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR).Results: PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p &lt; 0.01), peak SBP (155.8 vs. 170.8 mmHg, p &lt; 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p &lt; 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m(2), respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m(2), p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found.Conclusions: This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NU21-04-00445" target="_blank" >NU21-04-00445: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Neurology

ISSN

1351-5101

e-ISSN

1468-1331

Svazek periodika

31

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

"e16110"

Kód UT WoS článku

001091935300001

EID výsledku v databázi Scopus

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