Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00080538" target="_blank" >RIV/00159816:_____/24:00080538 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00135655

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1353802024000439" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1353802024000439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parkreldis.2024.106031" target="_blank" >10.1016/j.parkreldis.2024.106031</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

Popis výsledku v původním jazyce

Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre -dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender -matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed -based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between -group differences and neuropsychological scores of interest (visuospatial and executive domains z -scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre -dementia stages and enhance research of disease modifying therapy.

Název v anglickém jazyce

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

Popis výsledku anglicky

Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre -dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender -matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed -based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between -group differences and neuropsychological scores of interest (visuospatial and executive domains z -scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre -dementia stages and enhance research of disease modifying therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parkinsonism &amp; Related Disorders

ISSN

1353-8020

e-ISSN

1873-5126

Svazek periodika

121

Číslo periodika v rámci svazku

2024

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

106031

Kód UT WoS článku

001188128400001

EID výsledku v databázi Scopus

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