Evaluation of an effect of profundoplasty on peripheral tissue perfusion in patients with peripheral arterial disease using transcutaneous oximetry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00081438" target="_blank" >RIV/00159816:_____/24:00081438 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00138657

Výsledek na webu

<a href="https://e-coretvasa.cz/artkey/cor-202405-0001_evaluation-of-an-effect-of-profundoplasty-on-peripheral-tissue-perfusion-in-patients-with-peripheral-arterial-d.php?l=cz" target="_blank" >https://e-coretvasa.cz/artkey/cor-202405-0001_evaluation-of-an-effect-of-profundoplasty-on-peripheral-tissue-perfusion-in-patients-with-peripheral-arterial-d.php?l=cz</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33678/cor.2024.065" target="_blank" >10.33678/cor.2024.065</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of an effect of profundoplasty on peripheral tissue perfusion in patients with peripheral arterial disease using transcutaneous oximetry

Popis výsledku v původním jazyce

Introduction: Profunda femoris artery (PFA) is an important artery that provides perfusion of the lower limb tissues via collateral circulation in case of superficial femoral artery (SFA) occlusion. Isolated angiovascular reconstruction, APF reconstruction (profundoplasty), is a debated topic in the scientific literature regarding the importance of collateral circulation and its contribution to improving the patient&apos;s clinical condition. This project aims to evaluate the impact of isolated profundoplasty on the improvement of lower limb perfusion and thus to contribute to the decision-making process for the indication of this type of procedure. Methods: This prospective single-center study enrolled patients with peripheral artery disease (PAD) in the stage of claudication, rest pain or presence of tissue foot ulcer assessed according to Rutherford classification grade 1 to 5. Inclusion criteria were significant AFP stenosis with concomitant AFS closure and no distal runoff to the feet. Changes in claudication interval, Rutherford classification, and presence of chronic limb-threatening ischemia (CLTI) were assessed at one and six months after surgery. Transcutaneous oxygen tension (TcpO2) was measured to objectify the tissue perfusion and oxygenation level. Results: During two years, profundoplasty was performed in 45 patients, 23 claudicants, and 22 CLTI patients (9 with rest pain, 13 with foot ulcer). The claudicant group&apos;s intermittent claudication interval was prolonged from average 128 metres (m) preoperatively to 505 m six months after revascularization. In the CLTI group, there was a significant improvement and disappearance of rest pain in all patients, which was objectified by an improvement in TcpO2 on the calf by 52% to 52 mmHg and on the dorsum of the foot by 143% to 35.8 mmHg. Controlling the fate of more severe forms of CLTI by isolated profundoplasty alone is already a more difficult task, and even so, healing of the acral ischemic defect occurred in 61.5% of patients with amputation free survival at six months of 76%, with three patients undergoing high amputation in the thigh during follow-up. Postoperatively, an increase in TcpO2 values was also observed in patients with the foot ulcer, with 1.3 and 1.6 times increases in the tibia and calcaneus (to 43 mmHg and 27 mmHg, respectively). Conclusion: Profundoplasty as an isolated procedure for revascularization of patients with PAD remains the method of choice in a selective group of patients. Our study shows it is the most effective for treating rest pain. However, it may contribute to healing of smaller acral ulcers or prolong the claudication interval. The lack of consensus in the literature on the so-called TcpO2 threshold for defect healing was observed by our study at 27 mmHg and 35.8 mmHg for resolution of rest pain, respectively.

Název v anglickém jazyce

Evaluation of an effect of profundoplasty on peripheral tissue perfusion in patients with peripheral arterial disease using transcutaneous oximetry

Popis výsledku anglicky

Introduction: Profunda femoris artery (PFA) is an important artery that provides perfusion of the lower limb tissues via collateral circulation in case of superficial femoral artery (SFA) occlusion. Isolated angiovascular reconstruction, APF reconstruction (profundoplasty), is a debated topic in the scientific literature regarding the importance of collateral circulation and its contribution to improving the patient&apos;s clinical condition. This project aims to evaluate the impact of isolated profundoplasty on the improvement of lower limb perfusion and thus to contribute to the decision-making process for the indication of this type of procedure. Methods: This prospective single-center study enrolled patients with peripheral artery disease (PAD) in the stage of claudication, rest pain or presence of tissue foot ulcer assessed according to Rutherford classification grade 1 to 5. Inclusion criteria were significant AFP stenosis with concomitant AFS closure and no distal runoff to the feet. Changes in claudication interval, Rutherford classification, and presence of chronic limb-threatening ischemia (CLTI) were assessed at one and six months after surgery. Transcutaneous oxygen tension (TcpO2) was measured to objectify the tissue perfusion and oxygenation level. Results: During two years, profundoplasty was performed in 45 patients, 23 claudicants, and 22 CLTI patients (9 with rest pain, 13 with foot ulcer). The claudicant group&apos;s intermittent claudication interval was prolonged from average 128 metres (m) preoperatively to 505 m six months after revascularization. In the CLTI group, there was a significant improvement and disappearance of rest pain in all patients, which was objectified by an improvement in TcpO2 on the calf by 52% to 52 mmHg and on the dorsum of the foot by 143% to 35.8 mmHg. Controlling the fate of more severe forms of CLTI by isolated profundoplasty alone is already a more difficult task, and even so, healing of the acral ischemic defect occurred in 61.5% of patients with amputation free survival at six months of 76%, with three patients undergoing high amputation in the thigh during follow-up. Postoperatively, an increase in TcpO2 values was also observed in patients with the foot ulcer, with 1.3 and 1.6 times increases in the tibia and calcaneus (to 43 mmHg and 27 mmHg, respectively). Conclusion: Profundoplasty as an isolated procedure for revascularization of patients with PAD remains the method of choice in a selective group of patients. Our study shows it is the most effective for treating rest pain. However, it may contribute to healing of smaller acral ulcers or prolong the claudication interval. The lack of consensus in the literature on the so-called TcpO2 threshold for defect healing was observed by our study at 27 mmHg and 35.8 mmHg for resolution of rest pain, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

1803-7712

Svazek periodika

66

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

474-480

Kód UT WoS článku

001410859200001

EID výsledku v databázi Scopus

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