Extracellular histones profiles of pediatric H3K27-altered diffuse midline glioma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00081673" target="_blank" >RIV/00159816:_____/25:00081673 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s40291-024-00754-6" target="_blank" >https://link.springer.com/article/10.1007/s40291-024-00754-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40291-024-00754-6" target="_blank" >10.1007/s40291-024-00754-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Extracellular histones profiles of pediatric H3K27-altered diffuse midline glioma

Popis výsledku v původním jazyce

yocardial deformation imaging is a very attractive clinical tool for the assessment of right ventricular (RV) systolic performance, providing incremental diagnostic and prognostic information over the traditional indices of RV function. Among various imaging modalities, echocardiography is currently the Diffuse midline glioma, H3 K27-altered (DMG) is a fatal tumour that arises in the midline structures of the brain. When located in the pons, it is more commonly referred to as diffuse intrinsic pontine glioma (DIPG). DMG/DIPG is usually diagnosed when children are &lt; 10 years, and it has a median overall survival of &lt; 12 months after diagnosis. Radiological imaging is still the gold standard for DIPG diagnosis while the use of biopsy procedures led to our knowledge on its biology, such as with the identification of the canonical histone H3K27M mutation. However, the need to improve survival encourages the development of non-invasive, fast and inexpensive assays on biofluids for optimizing molecular diagnoses in DMG/DIPG. Here, we propose a rapid, new, imaging and epigenetics-based approach to diagnose DMG/DIPG in the plasma of paediatric patients.

Název v anglickém jazyce

Extracellular histones profiles of pediatric H3K27-altered diffuse midline glioma

Popis výsledku anglicky

yocardial deformation imaging is a very attractive clinical tool for the assessment of right ventricular (RV) systolic performance, providing incremental diagnostic and prognostic information over the traditional indices of RV function. Among various imaging modalities, echocardiography is currently the Diffuse midline glioma, H3 K27-altered (DMG) is a fatal tumour that arises in the midline structures of the brain. When located in the pons, it is more commonly referred to as diffuse intrinsic pontine glioma (DIPG). DMG/DIPG is usually diagnosed when children are &lt; 10 years, and it has a median overall survival of &lt; 12 months after diagnosis. Radiological imaging is still the gold standard for DIPG diagnosis while the use of biopsy procedures led to our knowledge on its biology, such as with the identification of the canonical histone H3K27M mutation. However, the need to improve survival encourages the development of non-invasive, fast and inexpensive assays on biofluids for optimizing molecular diagnoses in DMG/DIPG. Here, we propose a rapid, new, imaging and epigenetics-based approach to diagnose DMG/DIPG in the plasma of paediatric patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30300 - Health sciences

Projekt

<a href="/cs/project/NU23-03-00318" target="_blank" >NU23-03-00318: Volně cirkulující histonové komplexy jako diagnostický nástroj dětských nádorových onemocnění centrálního nervového systému (CNS).</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular diagnosis and therapy

ISSN

1177-1062

e-ISSN

1179-2000

Svazek periodika

29

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

13

Strana od-do

129-141

Kód UT WoS článku

001351167600002

EID výsledku v databázi Scopus

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