Increased pre-alpha functional connectivity in dementia with Lewy bodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082232" target="_blank" >RIV/00159816:_____/25:00082232 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143845

Výsledek na webu

<a href="https://journals.sagepub.com/doi/10.1177/13872877251385424" target="_blank" >https://journals.sagepub.com/doi/10.1177/13872877251385424</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/13872877251385424" target="_blank" >10.1177/13872877251385424</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased pre-alpha functional connectivity in dementia with Lewy bodies

Popis výsledku v původním jazyce

Background Resting-state EEG studies have shown that neurodegenerative dementias like Alzheimer&apos;s disease (AD) and dementia with Lewy bodies (DLB) can alter cortical functional connectivity. In DLB, the presence of a pre-alpha rhythm suggests frequency-specific network dysfunctions that remain poorly understood.Objective In the present study we tested the hypothesis that electroencephalography (EEG) recordings in DLB patients may show abnormal cortical functional connectivity.Methods Resting-state EEG activity was recorded in 73 DLB, 70 AD, and 41 healthy control (HC) participants from seven European DLB Consortium Centers. We used eLORETA to calculate lagged linear connectivity (LLC) from EEG sources at delta, theta, pre-alpha, alpha, beta, gamma bands.Results Statistical analyses revealed greater fronto-occipital connectivity at the theta and pre-alpha bands in the DLB group compared to the AD and HC groups. Furthermore, the DLB and AD groups displayed reduced alpha LLC compared to the HC group.Conclusions The results suggest that in DLB patients, resting-state EEG pre-alpha activity is not a local process. Instead, it may reflect enhanced functional connectivity, possibly propagating dysfunctional thalamocortical connectivity, within long fronto-occipital tracts.

Název v anglickém jazyce

Increased pre-alpha functional connectivity in dementia with Lewy bodies

Popis výsledku anglicky

Background Resting-state EEG studies have shown that neurodegenerative dementias like Alzheimer&apos;s disease (AD) and dementia with Lewy bodies (DLB) can alter cortical functional connectivity. In DLB, the presence of a pre-alpha rhythm suggests frequency-specific network dysfunctions that remain poorly understood.Objective In the present study we tested the hypothesis that electroencephalography (EEG) recordings in DLB patients may show abnormal cortical functional connectivity.Methods Resting-state EEG activity was recorded in 73 DLB, 70 AD, and 41 healthy control (HC) participants from seven European DLB Consortium Centers. We used eLORETA to calculate lagged linear connectivity (LLC) from EEG sources at delta, theta, pre-alpha, alpha, beta, gamma bands.Results Statistical analyses revealed greater fronto-occipital connectivity at the theta and pre-alpha bands in the DLB group compared to the AD and HC groups. Furthermore, the DLB and AD groups displayed reduced alpha LLC compared to the HC group.Conclusions The results suggest that in DLB patients, resting-state EEG pre-alpha activity is not a local process. Instead, it may reflect enhanced functional connectivity, possibly propagating dysfunctional thalamocortical connectivity, within long fronto-occipital tracts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Alzheimers Disease

ISSN

1387-2877

e-ISSN

1875-8908

Svazek periodika

108

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

1132-1143

Kód UT WoS článku

001589903100001

EID výsledku v databázi Scopus

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