Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082328" target="_blank" >RIV/00159816:_____/25:00082328 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00140726 RIV/00023736:_____/25:00013780

Výsledek na webu

<a href="https://www.nature.com/articles/s12276-025-01397-1" target="_blank" >https://www.nature.com/articles/s12276-025-01397-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s12276-025-01397-1" target="_blank" >10.1038/s12276-025-01397-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue

Popis výsledku v původním jazyce

The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut-brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated the effects of serotonin, a neuromodulator produced in the gut, on immune cell and intestinal tissue interactions. Serotonin attenuated the tumor necrosis factor-induced proinflammatory response, mostly by affecting the expression of chemokines. Serotonin affected the phenotype and distribution of tissue-migrating monocytes, without direct contact with the cells, by remodeling the intestinal tissue. Collectively, our results show that serotonin plays a crucial role in communication among gut-brain axis components and regulates monocyte migration and plasticity, thereby contributing to gut homeostasis and the progression of inflammation. In vivo studies focused on the role of neuromodulators in gut inflammation have shown controversial results, highlighting the importance of human experimental models. Moreover, our results emphasize the importance of human health research in human cell-based models and suggest that the serotonin signaling pathway is a new therapeutic target for inflammatory bowel disease.

Název v anglickém jazyce

Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue

Popis výsledku anglicky

The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut-brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated the effects of serotonin, a neuromodulator produced in the gut, on immune cell and intestinal tissue interactions. Serotonin attenuated the tumor necrosis factor-induced proinflammatory response, mostly by affecting the expression of chemokines. Serotonin affected the phenotype and distribution of tissue-migrating monocytes, without direct contact with the cells, by remodeling the intestinal tissue. Collectively, our results show that serotonin plays a crucial role in communication among gut-brain axis components and regulates monocyte migration and plasticity, thereby contributing to gut homeostasis and the progression of inflammation. In vivo studies focused on the role of neuromodulators in gut inflammation have shown controversial results, highlighting the importance of human experimental models. Moreover, our results emphasize the importance of human health research in human cell-based models and suggest that the serotonin signaling pathway is a new therapeutic target for inflammatory bowel disease.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EXPERIMENTAL AND MOLECULAR MEDICINE

ISSN

1226-3613

e-ISSN

2092-6413

Svazek periodika

57

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

KR - Korejská republika

Počet stran výsledku

15

Strana od-do

364-378

Kód UT WoS článku

001410786000001

EID výsledku v databázi Scopus

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