Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082418" target="_blank" >RIV/00159816:_____/25:00082418 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00141927 RIV/00216305:26220/26:0198293

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ene.70151" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ene.70151</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.70151" target="_blank" >10.1111/ene.70151</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy

Popis výsledku v původním jazyce

BackgroundMusic-based neuromodulation has garnered interest as a potential therapeutic approach for drug-resistant epilepsy. This study expands on prior research by examining the effects of different musical features on interictal epileptiform discharges (IEDs) within intracerebral EEG (iEEG).MethodsTwenty-five patients with drug-resistant epilepsy undergoing presurgical iEEG evaluation participated in the study. Over 2 days, patients listened to various musical compositions characterized by distinct acoustic properties. EEG measurements were recorded before and after each listening session to evaluate IED changes.ResultsThe study identified individualized patterns in IED reduction, with certain acoustic properties showing consistent effects across musical genres. Mozart&apos;s &quot;Piano Concerto No. 27&quot; K 595c globally reduced IEDs by 28% while listening to music (p = 0.0191) and 19% in the postmusic resting state (p = 0.0111); relaxation music increased IEDs by 55% (p = 0.0197). Based on the acoustic analysis of individuals, we identified compositions that significantly reduced IEDs, with reductions ranging from 32% to 44% (p = 0.0001). In contrast, compositions with differing acoustic properties did not result in significant changes in IEDs. These results suggest that specific acoustic properties, rather than genre, primarily influence IEDs.ConclusionsThe findings suggest that specific acoustic properties can influence brain activity in a reproducible manner at the individual level, modulating IEDs based on personalized testing and selection across a spectrum of musical genres. These results suggest the potential for music-based neuromodulation as a personalized therapeutic approach in epilepsy management, emphasizing the importance of acoustic features over musical genre. Further research is needed to explore individual aspects of music-based interventions.

Název v anglickém jazyce

Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy

Popis výsledku anglicky

BackgroundMusic-based neuromodulation has garnered interest as a potential therapeutic approach for drug-resistant epilepsy. This study expands on prior research by examining the effects of different musical features on interictal epileptiform discharges (IEDs) within intracerebral EEG (iEEG).MethodsTwenty-five patients with drug-resistant epilepsy undergoing presurgical iEEG evaluation participated in the study. Over 2 days, patients listened to various musical compositions characterized by distinct acoustic properties. EEG measurements were recorded before and after each listening session to evaluate IED changes.ResultsThe study identified individualized patterns in IED reduction, with certain acoustic properties showing consistent effects across musical genres. Mozart&apos;s &quot;Piano Concerto No. 27&quot; K 595c globally reduced IEDs by 28% while listening to music (p = 0.0191) and 19% in the postmusic resting state (p = 0.0111); relaxation music increased IEDs by 55% (p = 0.0197). Based on the acoustic analysis of individuals, we identified compositions that significantly reduced IEDs, with reductions ranging from 32% to 44% (p = 0.0001). In contrast, compositions with differing acoustic properties did not result in significant changes in IEDs. These results suggest that specific acoustic properties, rather than genre, primarily influence IEDs.ConclusionsThe findings suggest that specific acoustic properties can influence brain activity in a reproducible manner at the individual level, modulating IEDs based on personalized testing and selection across a spectrum of musical genres. These results suggest the potential for music-based neuromodulation as a personalized therapeutic approach in epilepsy management, emphasizing the importance of acoustic features over musical genre. Further research is needed to explore individual aspects of music-based interventions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Neurology

ISSN

1351-5101

e-ISSN

1468-1331

Svazek periodika

32

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

"e70151"

Kód UT WoS článku

001546468300002

EID výsledku v databázi Scopus

—