The role of the somatosensory cortex in self-paced movement impairment in Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082455" target="_blank" >RIV/00159816:_____/25:00082455 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00140690

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1388245725000100" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388245725000100</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2025.01.001" target="_blank" >10.1016/j.clinph.2025.01.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of the somatosensory cortex in self-paced movement impairment in Parkinson's disease

Popis výsledku v původním jazyce

Objective: The aim of this work was to study the differences at the whole-brain level between self-paced and cued movement processing in Parkinson&apos;s disease (PD). Methods: High density electroencephalogram (HD-EEG) was recorded during the performance of self-paced movements (Bereitschaftspotential - BP) and visually cued movements (VMT) in PD patients (n = 38) and in a group of healthy controls (HC, n = 23). Oscillatory changes in the alpha, beta, and gamma frequencies were evaluated and correlated to the clinical scales- MDS-UPDRS and Freezing of Gait Questionnaire (FOGQ). Results: The main difference in the alpha range was an activation in the basal ganglia area during VMT performance as compared to BP performance; this activation was present only in HC. The most important finding was observed in the high beta range: a higher activation of the right postcentral area during BP performance in PD subjects as compared to HC, correlating to the severity of FOG. Moreover, PD patients had lower gamma activation of the right frontal areas. Conclusion: A simplification of motor circuits and a hyperactivation of the right somatosensory cortex were observed in PD subjects. Significance: Future studies should be focused on this area to confirm or disprove its role in FOG.

Název v anglickém jazyce

The role of the somatosensory cortex in self-paced movement impairment in Parkinson's disease

Popis výsledku anglicky

Objective: The aim of this work was to study the differences at the whole-brain level between self-paced and cued movement processing in Parkinson&apos;s disease (PD). Methods: High density electroencephalogram (HD-EEG) was recorded during the performance of self-paced movements (Bereitschaftspotential - BP) and visually cued movements (VMT) in PD patients (n = 38) and in a group of healthy controls (HC, n = 23). Oscillatory changes in the alpha, beta, and gamma frequencies were evaluated and correlated to the clinical scales- MDS-UPDRS and Freezing of Gait Questionnaire (FOGQ). Results: The main difference in the alpha range was an activation in the basal ganglia area during VMT performance as compared to BP performance; this activation was present only in HC. The most important finding was observed in the high beta range: a higher activation of the right postcentral area during BP performance in PD subjects as compared to HC, correlating to the severity of FOG. Moreover, PD patients had lower gamma activation of the right frontal areas. Conclusion: A simplification of motor circuits and a hyperactivation of the right somatosensory cortex were observed in PD subjects. Significance: Future studies should be focused on this area to confirm or disprove its role in FOG.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Svazek periodika

171

Číslo periodika v rámci svazku

Mar 2025

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

11-17

Kód UT WoS článku

001409721100001

EID výsledku v databázi Scopus

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