Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082525" target="_blank" >RIV/00159816:_____/25:00082525 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10498926 RIV/00064203:_____/25:10498926

Výsledek na webu

<a href="https://www.nature.com/articles/s41588-025-02227-w" target="_blank" >https://www.nature.com/articles/s41588-025-02227-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41588-025-02227-w" target="_blank" >10.1038/s41588-025-02227-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Popis výsledku v původním jazyce

A polygenic score (PGS) for Alzheimer&apos;s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.

Název v anglickém jazyce

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Popis výsledku anglicky

A polygenic score (PGS) for Alzheimer&apos;s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30101 - Human genetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Genetics

ISSN

1061-4036

e-ISSN

1546-1718

Svazek periodika

57

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

24

Strana od-do

nestránkováno

Kód UT WoS článku

001511340900001

EID výsledku v databázi Scopus

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