Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F10%3A10084225" target="_blank" >RIV/00179906:_____/10:10084225 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17310/10:A1100Z1N RIV/00843989:_____/10:00101357

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

Popis výsledku v původním jazyce

Objectives: Hepatitis B vaccination in children born to hepatitis B surface antigen positive mothers considerably decreased risk of the vertical transmission. Methods: Combine passive-active immunisation was used in 665 newborns of HBsAg positive mothersin the period 1988-2006 years. Results: Protective anti-HBs level after immunisation was proved in 574 of 620 children (93 %). Persistence of protective anti-HBs antibodies was detected in 70 %, 40 % and 25 % children in 5, 10 and 15 years of life. Vertical transmission with chronic HBsAg carrier status was detected in 2 infants. Anti-HBc seroconversion was proven in 10 children from 3 to 15 years of age. Natural boosting with an anti-HBs increase was detected in 38 children. Conclusions: Combined active-passive immunisation of newborns against hepatitis B provides persistent protection up to adolescence despite frequent waning anti-HBs antibodies.

Název v anglickém jazyce

Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

Popis výsledku anglicky

Objectives: Hepatitis B vaccination in children born to hepatitis B surface antigen positive mothers considerably decreased risk of the vertical transmission. Methods: Combine passive-active immunisation was used in 665 newborns of HBsAg positive mothersin the period 1988-2006 years. Results: Protective anti-HBs level after immunisation was proved in 574 of 620 children (93 %). Persistence of protective anti-HBs antibodies was detected in 70 %, 40 % and 25 % children in 5, 10 and 15 years of life. Vertical transmission with chronic HBsAg carrier status was detected in 2 infants. Anti-HBc seroconversion was proven in 10 children from 3 to 15 years of age. Natural boosting with an anti-HBs increase was detected in 38 children. Conclusions: Combined active-passive immunisation of newborns against hepatitis B provides persistent protection up to adolescence despite frequent waning anti-HBs antibodies.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9275" target="_blank" >NR9275: Vakcinace novorozenců HBsAg pozitivních matek - dlouhodobé hodnocení účinnosti vakcinace</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection

ISSN

0300-8126

e-ISSN

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Svazek periodika

38

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000282222200008

EID výsledku v databázi Scopus

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