Application of the comet assay method in clinical studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10106378" target="_blank" >RIV/00179906:_____/11:10106378 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/11:00002574 RIV/00216208:11160/11:10106378

Výsledek na webu

<a href="http://www.springerlink.com/content/37563j1456117247/fulltext.pdf" target="_blank" >http://www.springerlink.com/content/37563j1456117247/fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00508-011-0066-0" target="_blank" >10.1007/s00508-011-0066-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Application of the comet assay method in clinical studies

Popis výsledku v původním jazyce

The comet assay or single-cell gel electrophoresis (SCGE) assay is now widely accepted as a standard method for assessing DNA damage in individual cells.The comet assay should be eminently suitable for use in clinical practice since it is a relatively simple and inexpensive technique which requires only a few cells, and results can be obtained within a matter of hours.This method can be used in the study of cancer as well as in lifestyle and dietary studies. In cancer it is useful for measuring DNA damage before, throughout and after therapy (either radiotherapy or chemotherapy). Another use of this method is in lifestyle study, such as investigation of the effect on DNA of common human activities (e.g. smoking, or working with a potentially genotoxicagent). The final use of comet assay in this paper is dietary study. In this type of study we observe the effects of consumption of specific foods or supplements which may be protective for DNA against damage.

Název v anglickém jazyce

Application of the comet assay method in clinical studies

Popis výsledku anglicky

The comet assay or single-cell gel electrophoresis (SCGE) assay is now widely accepted as a standard method for assessing DNA damage in individual cells.The comet assay should be eminently suitable for use in clinical practice since it is a relatively simple and inexpensive technique which requires only a few cells, and results can be obtained within a matter of hours.This method can be used in the study of cancer as well as in lifestyle and dietary studies. In cancer it is useful for measuring DNA damage before, throughout and after therapy (either radiotherapy or chemotherapy). Another use of this method is in lifestyle study, such as investigation of the effect on DNA of common human activities (e.g. smoking, or working with a potentially genotoxicagent). The final use of comet assay in this paper is dietary study. In this type of study we observe the effects of consumption of specific foods or supplements which may be protective for DNA against damage.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Wiener Klinische Wochenschrift

ISSN

0043-5325

e-ISSN

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Svazek periodika

123

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

693-699

Kód UT WoS článku

000298854400001

EID výsledku v databázi Scopus

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