Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation

Popis výsledku v původním jazyce

The aim of the study performed at 29 patients undergoing autologous peripheral blood progenitor cell (PBPC) transplantation was to obtain data on total number of thawed infused nucleated cells and on their viability as well as on the number of infused CD34+ cells and CFU-GM. To prevent delayed engraftment (more than 21 days) the minimum cell dose per kg of patient's weight was adjusted to 2x10exp6 CD34+ and 2x10exp5 CFU-GM. As the PBPC concentrates were cryopreserved in presence of 10% dimethylsulphoxide (DMSO) the consequences of this approach on the total infused volume were evaluated. Engraftment within 21 days was achieved in 97 % of patients. The effort to control the risk of delayed engraftment led, however, to the need to accept higher risk of DMSO toxicity.

Název v anglickém jazyce

Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation

Popis výsledku anglicky

The aim of the study performed at 29 patients undergoing autologous peripheral blood progenitor cell (PBPC) transplantation was to obtain data on total number of thawed infused nucleated cells and on their viability as well as on the number of infused CD34+ cells and CFU-GM. To prevent delayed engraftment (more than 21 days) the minimum cell dose per kg of patient's weight was adjusted to 2x10exp6 CD34+ and 2x10exp5 CFU-GM. As the PBPC concentrates were cryopreserved in presence of 10% dimethylsulphoxide (DMSO) the consequences of this approach on the total infused volume were evaluated. Engraftment within 21 days was achieved in 97 % of patients. The effort to control the risk of delayed engraftment led, however, to the need to accept higher risk of DMSO toxicity.

Druh

D - Stať ve sborníku

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

23rd IIR International Congress of Refrigeration

ISBN

978-2-913149-88-5

ISSN

1025-9031

e-ISSN

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Počet stran výsledku

4

Strana od-do

3609-3612

Název nakladatele

International Institute of Refrigeration

Místo vydání

Praha

Místo konání akce

Prague, Czech Republic

Datum konání akce

21. 8. 2011

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000310485802003