Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10123429" target="_blank" >RIV/00179906:_____/12:10123429 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10123429

Výsledek na webu

<a href="http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000335491&Ausgabe=256730&ProduktNr=224274&filename=000335491.pdf" target="_blank" >http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000335491&Ausgabe=256730&ProduktNr=224274&filename=000335491.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000335491" target="_blank" >10.1159/000335491</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

Popis výsledku v původním jazyce

Aim:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. Methods: Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group after orchidectomy (ORX+AML) received SLD enriched with amlodipine for 12 weeks. Bone marker concentrations in serum of PINP, OPG and IGF-1, and the levels of CTX-I, BAP and BMP-2 in a bonehomogenate were measured using enzyme-linked immuno-sorbent assay. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. The femurs were used for biomechanical testing. Results: Bone markers (CTX-I, BAP, BMP-2) in ORX were higherversus SHAM. In ORX+AML there was a decrease in PINP, CTX-I, BAP, BMP-2 and OPG versus ORX. IGF-1 was decreased in ORX versus SHAM. In ORX+AML it was increased versus ORX. In ORX, a decrease was demonstrated versus SHAM in BMD of the whol

Název v anglickém jazyce

Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

Popis výsledku anglicky

Aim:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. Methods: Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group after orchidectomy (ORX+AML) received SLD enriched with amlodipine for 12 weeks. Bone marker concentrations in serum of PINP, OPG and IGF-1, and the levels of CTX-I, BAP and BMP-2 in a bonehomogenate were measured using enzyme-linked immuno-sorbent assay. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. The femurs were used for biomechanical testing. Results: Bone markers (CTX-I, BAP, BMP-2) in ORX were higherversus SHAM. In ORX+AML there was a decrease in PINP, CTX-I, BAP, BMP-2 and OPG versus ORX. IGF-1 was decreased in ORX versus SHAM. In ORX+AML it was increased versus ORX. In ORX, a decrease was demonstrated versus SHAM in BMD of the whol

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmacology

ISSN

0031-7012

e-ISSN

—

Svazek periodika

89

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

37-43

Kód UT WoS článku

000301911600007

EID výsledku v databázi Scopus

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