Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10123846" target="_blank" >RIV/00179906:_____/12:10123846 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/12:10123846 RIV/00216208:11160/12:10123846

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0014299912005468" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0014299912005468</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejphar.2012.06.034" target="_blank" >10.1016/j.ejphar.2012.06.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats

Popis výsledku v původním jazyce

The present paper describes our investigation of the effect of epigallocatechin-gallate (EGCG), the major active ingredient from the green tea, on liver cholesterol metabolism in control and ethinylestradiol-treated rats. The results demonstrated that EGCG administration to control rats did not change plasma total cholesterol, but reduced VLDL cholesterol. However, EGCG markedly enhanced biliary cholesterol and phospholipid secretion, despite the decrease in bile flow and biliary bile acid secretion. Inethinylestradiol treated rats, EGCG caused reduction in hepatic cholesterol accumulation and consequently also mitigation of drug-induced hepatomegaly. These effect of EGCG were attributable to its inducing effect on protein expression of ATP-binding cassette transporter G5 and 8 (ABCG5/8) - i.e. cholesterol biliary exporter, and the reduced expression of acyl-CoA:cholesterol acyltransferase (ACAT2) protein - i.e. limiting step for cholesterol liver storage and VLDL production. Our data

Název v anglickém jazyce

Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats

Popis výsledku anglicky

The present paper describes our investigation of the effect of epigallocatechin-gallate (EGCG), the major active ingredient from the green tea, on liver cholesterol metabolism in control and ethinylestradiol-treated rats. The results demonstrated that EGCG administration to control rats did not change plasma total cholesterol, but reduced VLDL cholesterol. However, EGCG markedly enhanced biliary cholesterol and phospholipid secretion, despite the decrease in bile flow and biliary bile acid secretion. Inethinylestradiol treated rats, EGCG caused reduction in hepatic cholesterol accumulation and consequently also mitigation of drug-induced hepatomegaly. These effect of EGCG were attributable to its inducing effect on protein expression of ATP-binding cassette transporter G5 and 8 (ABCG5/8) - i.e. cholesterol biliary exporter, and the reduced expression of acyl-CoA:cholesterol acyltransferase (ACAT2) protein - i.e. limiting step for cholesterol liver storage and VLDL production. Our data

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmacology

ISSN

0014-2999

e-ISSN

—

Svazek periodika

691

Číslo periodika v rámci svazku

1-3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

38-45

Kód UT WoS článku

000307815800005

EID výsledku v databázi Scopus

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