Methylation in the p53 promoter in epithelial ovarian cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10126505" target="_blank" >RIV/00179906:_____/13:10126505 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/13:10126505

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs12094-012-0894-z" target="_blank" >http://link.springer.com/article/10.1007%2Fs12094-012-0894-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12094-012-0894-z" target="_blank" >10.1007/s12094-012-0894-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Methylation in the p53 promoter in epithelial ovarian cancer

Popis výsledku v původním jazyce

Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing andtumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer.

Název v anglickém jazyce

Methylation in the p53 promoter in epithelial ovarian cancer

Popis výsledku anglicky

Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing andtumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and Translational Oncology

ISSN

1699-048X

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

4

Strana od-do

160-163

Kód UT WoS článku

000314280500011

EID výsledku v databázi Scopus

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