Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10132976" target="_blank" >RIV/00179906:_____/13:10132976 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/13:43874761 RIV/62690094:18470/13:50001174
Výsledek na webu
<a href="http://link.springer.com/article/10.1007%2Fs12640-012-9329-4#page-1" target="_blank" >http://link.springer.com/article/10.1007%2Fs12640-012-9329-4#page-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12640-012-9329-4" target="_blank" >10.1007/s12640-012-9329-4</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
Popis výsledku v původním jazyce
The blood-brain barrier plays a vital role in the protection of the central nervous system. It is composed of endothelial cells with tight-junctions to limit the penetration of many endogenous and exogenous compounds, particularly hydrophilic xenobiotics. Nerve agents and pesticides are groups of compounds with high penetration potential into the central nervous system. However, oxime type antidotes are known to penetrate blood-brain barrier only in low concentration. The aim of presented study is to describe the pharmacokinetic profile of oxime K027 a novel antidote candidate. The main focus is on penetration of tested substance into the selected brain regions following time-dependent manner. The maximum concentration of the oxime K027 was attaining 15 and 30 min after i.m. application in plasma and brain tissue, respectively. The perfused brain tissue concentration was relatively high (10(-7) M order of magnitude) and depending on the brain region it was constant 15-60 min after appl
Název v anglickém jazyce
Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
Popis výsledku anglicky
The blood-brain barrier plays a vital role in the protection of the central nervous system. It is composed of endothelial cells with tight-junctions to limit the penetration of many endogenous and exogenous compounds, particularly hydrophilic xenobiotics. Nerve agents and pesticides are groups of compounds with high penetration potential into the central nervous system. However, oxime type antidotes are known to penetrate blood-brain barrier only in low concentration. The aim of presented study is to describe the pharmacokinetic profile of oxime K027 a novel antidote candidate. The main focus is on penetration of tested substance into the selected brain regions following time-dependent manner. The maximum concentration of the oxime K027 was attaining 15 and 30 min after i.m. application in plasma and brain tissue, respectively. The perfused brain tissue concentration was relatively high (10(-7) M order of magnitude) and depending on the brain region it was constant 15-60 min after appl
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ME09086" target="_blank" >ME09086: Vývoj nových antidotních prostředků proti organofosforovým pesticidům</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neurotoxicity Research
ISSN
1029-8428
e-ISSN
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Svazek periodika
23
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
63-68
Kód UT WoS článku
000312664800005
EID výsledku v databázi Scopus
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