The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10133853" target="_blank" >RIV/00179906:_____/13:10133853 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/13:10133853

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.atherosclerosissup.2012.10.019" target="_blank" >http://dx.doi.org/10.1016/j.atherosclerosissup.2012.10.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.atherosclerosissup.2012.10.019" target="_blank" >10.1016/j.atherosclerosissup.2012.10.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination

Popis výsledku v původním jazyce

Objective: Mean platelet volume is arousing increasing interest as a new independent cardiovascular risk factor. Large platelets are likely to be more reactive. If mean platelet volume would drop after LDL-lowering therapy, decreased MPV could be one ofthe markers of successful therapy. Therefore, we investigated mean platelet volume after extracorporeal LDL-cholesterol elimination. Methods: Mean platelet volume was investigated in patients with severe familial hypercholesterolemia long-term treated (3-12 years) by LDL-apheresis (immunoapheresis) or cascade filtration. Plasma was obtained by centrifugation. Adsorbers Lipopak 400 were used for immunoapheresis and filters Evaflux 4A were used for cascade filtration. 95 pair samples were measured (beforeand after the procedures) in a group of 12 patients - each patient 8 times in 4 years. Results: Mean platelet volume before the procedures was 10.891 fl, CI 10.25-11.53. Mean platelet volume after the procedures decreased - 10.478 fl, CI

Název v anglickém jazyce

The decrease of mean platelet volume after extracorporeal LDL-cholesterol elimination

Popis výsledku anglicky

Objective: Mean platelet volume is arousing increasing interest as a new independent cardiovascular risk factor. Large platelets are likely to be more reactive. If mean platelet volume would drop after LDL-lowering therapy, decreased MPV could be one ofthe markers of successful therapy. Therefore, we investigated mean platelet volume after extracorporeal LDL-cholesterol elimination. Methods: Mean platelet volume was investigated in patients with severe familial hypercholesterolemia long-term treated (3-12 years) by LDL-apheresis (immunoapheresis) or cascade filtration. Plasma was obtained by centrifugation. Adsorbers Lipopak 400 were used for immunoapheresis and filters Evaflux 4A were used for cascade filtration. 95 pair samples were measured (beforeand after the procedures) in a group of 12 patients - each patient 8 times in 4 years. Results: Mean platelet volume before the procedures was 10.891 fl, CI 10.25-11.53. Mean platelet volume after the procedures decreased - 10.478 fl, CI

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12287" target="_blank" >NT12287: Význam insulinové resistence v patogenezi kardiometabolického rizika u diabetes mellitus</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Atherosclerosis Supplements

ISSN

1567-5688

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

77-81

Kód UT WoS článku

000314885000014

EID výsledku v databázi Scopus

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