A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10159526" target="_blank" >RIV/00179906:_____/13:10159526 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/13:43874675

Výsledek na webu

<a href="http://informahealthcare.com/doi/abs/10.3109/15569527.2012.730087" target="_blank" >http://informahealthcare.com/doi/abs/10.3109/15569527.2012.730087</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/15569527.2012.730087" target="_blank" >10.3109/15569527.2012.730087</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Popis výsledku v původním jazyce

Objective: The genotoxic vesicant sulphur mustard [bis-2-(chloroethyl)sulphide] is a chemical warfare agent which is easily available due to its relatively simple synthesis. Thus, sulphur mustard is a potential agent for mass contamination. In this study, we focused on sulphur mustard toxicity and decontamination in a rat model using commercially available detergent mixtures for dermal decontamination. Methods: Male Wistar rats were percutaneously treated with sulphur mustard and subjected to wet decontamination 2 min postexposure. Commercially produced detergents NeodekontTM, ArgosTM, DermogelTM and FloraFreeTM were tested for their decontamination efficacy against an exposed group and their protective ratios determined. Results and conclusion: The results showed that all tested detergent solutions produced an increase in the median lethal dose [LD50 = 9.83 (5.87-13.63) mg.kgMINUS SIGN 1] in comparison to controls, which led to increased survival of experimental animals. In general, a

Název v anglickém jazyce

A comparison of decontamination effects of commercially available detergents in rats pre-exposed to topical sulphur mustard

Popis výsledku anglicky

Objective: The genotoxic vesicant sulphur mustard [bis-2-(chloroethyl)sulphide] is a chemical warfare agent which is easily available due to its relatively simple synthesis. Thus, sulphur mustard is a potential agent for mass contamination. In this study, we focused on sulphur mustard toxicity and decontamination in a rat model using commercially available detergent mixtures for dermal decontamination. Methods: Male Wistar rats were percutaneously treated with sulphur mustard and subjected to wet decontamination 2 min postexposure. Commercially produced detergents NeodekontTM, ArgosTM, DermogelTM and FloraFreeTM were tested for their decontamination efficacy against an exposed group and their protective ratios determined. Results and conclusion: The results showed that all tested detergent solutions produced an increase in the median lethal dose [LD50 = 9.83 (5.87-13.63) mg.kgMINUS SIGN 1] in comparison to controls, which led to increased survival of experimental animals. In general, a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cutaneous and Ocular Toxicology

ISSN

1556-9527

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

135-139

Kód UT WoS článku

000311234500008

EID výsledku v databázi Scopus

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