Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation Report of 3 Cases With the ETV6-NTRK3 Gene Fusion and Analysis of TP53, beta-Catenin, EGFR, and CCND1 Genes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10188736" target="_blank" >RIV/00179906:_____/14:10188736 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10188736 RIV/00216208:11140/14:10188736

Výsledek na webu

<a href="http://dx.doi.org/10.1097/PAS.0000000000000088" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000088</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAS.0000000000000088" target="_blank" >10.1097/PAS.0000000000000088</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation Report of 3 Cases With the ETV6-NTRK3 Gene Fusion and Analysis of TP53, beta-Catenin, EGFR, and CCND1 Genes

Popis výsledku v původním jazyce

Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15)(p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretions. Colloid-like secretory material stains positively for periodic acid-Schiff with and without diastase as well as for Alcian Blue. We present for the first time, 3 patients with MASC of the parotid gland in which high-grade (HG) transformation developed in each case characterized by an accelerated clinical course and poor outcome. The HG component revealed strong membrane staining for EGFR and ?-catenin, cytoplasmic/nuclear staining for S-100 protein, and

Název v anglickém jazyce

Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation Report of 3 Cases With the ETV6-NTRK3 Gene Fusion and Analysis of TP53, beta-Catenin, EGFR, and CCND1 Genes

Popis výsledku anglicky

Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15)(p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretions. Colloid-like secretory material stains positively for periodic acid-Schiff with and without diastase as well as for Alcian Blue. We present for the first time, 3 patients with MASC of the parotid gland in which high-grade (HG) transformation developed in each case characterized by an accelerated clinical course and poor outcome. The HG component revealed strong membrane staining for EGFR and ?-catenin, cytoplasmic/nuclear staining for S-100 protein, and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/NT13701" target="_blank" >NT13701: Exprese vaskulárního endoteliálního růstového faktoru VEGF-C/D a její význam pro lymfangioneogenezu, uzlinové metastázování a prognózu karcinomů slinných žláz.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Surgical Pathology

ISSN

0147-5185

e-ISSN

—

Svazek periodika

38

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

23-33

Kód UT WoS článku

000338983000003

EID výsledku v databázi Scopus

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