Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10272499" target="_blank" >RIV/00179906:_____/14:10272499 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11150/14:10272499 RIV/00216208:11160/14:10272499
Výsledek na webu
<a href="http://journals.lww.com/shockjournal/Fulltext/2014/10000/Deferoxamine_but_not_Dexrazoxane_Alleviates_Liver.13.aspx" target="_blank" >http://journals.lww.com/shockjournal/Fulltext/2014/10000/Deferoxamine_but_not_Dexrazoxane_Alleviates_Liver.13.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/SHK.0000000000000210" target="_blank" >10.1097/SHK.0000000000000210</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats
Popis výsledku v původním jazyce
The purpose of the present study was to compare the activity of two different clinically available iron chelators on the development of acute liver injury after administration of the bacterial endotoxin (lipopolysaccharide [LPS]) in rats. Lipopolysaccharide was administered either alone or after pretreatment with dexrazoxane (DEX) or deferoxamine (DFO). Control groups received only saline or its combination with either chelator. After 8 h, untreated LPS rats developed liver injury, with signs of inflammation and oxidative stress. Lipopolysaccharide reduced plasma iron concentrations in association with increased production of hepcidin and the reduced liver expression of ferroportin. Administration of chelating agents to LPS animals showed distinct effects. Although both drugs were able to reduce liver iron content, together with corresponding changes in hepcidin and ferroportin expressions, only DFO showed a protective effect against liver injury despite relatively small liver concentr
Název v anglickém jazyce
Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats
Popis výsledku anglicky
The purpose of the present study was to compare the activity of two different clinically available iron chelators on the development of acute liver injury after administration of the bacterial endotoxin (lipopolysaccharide [LPS]) in rats. Lipopolysaccharide was administered either alone or after pretreatment with dexrazoxane (DEX) or deferoxamine (DFO). Control groups received only saline or its combination with either chelator. After 8 h, untreated LPS rats developed liver injury, with signs of inflammation and oxidative stress. Lipopolysaccharide reduced plasma iron concentrations in association with increased production of hepcidin and the reduced liver expression of ferroportin. Administration of chelating agents to LPS animals showed distinct effects. Although both drugs were able to reduce liver iron content, together with corresponding changes in hepcidin and ferroportin expressions, only DFO showed a protective effect against liver injury despite relatively small liver concentr
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Shock
ISSN
1073-2322
e-ISSN
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Svazek periodika
42
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
372-379
Kód UT WoS článku
000342465100013
EID výsledku v databázi Scopus
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