The Role of Protein p16(INK4a) in Glottic Laryngeal Squamous Cell Carcinoma
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281758" target="_blank" >RIV/00179906:_____/14:10281758 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11140/14:10281758 RIV/00216208:11150/14:10281758
Výsledek na webu
<a href="http://download.springer.com/static/pdf/794/art%253A10.1007%252Fs12253-014-9773-y.pdf?auth66=1416393279_47d52c012a468b306ad30b2aaac4dc59&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/794/art%253A10.1007%252Fs12253-014-9773-y.pdf?auth66=1416393279_47d52c012a468b306ad30b2aaac4dc59&ext=.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12253-014-9773-y" target="_blank" >10.1007/s12253-014-9773-y</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Role of Protein p16(INK4a) in Glottic Laryngeal Squamous Cell Carcinoma
Popis výsledku v původním jazyce
Head and neck squamous cell cancer (HNSCC) includes tumors of various anatomical sites sharing the common etiological factors. However some differences in pathogenesis and prognosis of HNSCC have been hitherto documented. Laryngeal squamous cell carcinoma (LSCC) is one the most common type of the head and neck cancer. The majority of laryngeal cancers are located in the glottic area. P16 was recently documented to be important prognostic marker in many tumors including HNSCC. The aim of our study was toassess the significance of p16 expression in glottic LSCC. Fifty eight patients after surgical treatment of the glottic LSCC were enrolled in the retrospective study. The p16 expression was immunohistochemically detected and semiquantitatively evaluatedin tumor tissue. The results were statistically correlated with clinical and pathological parameters. Protein p16 was expressed in glottic LSCC of 15 patients (25.9 %). Statistically significant higher p16 overexpression was proven in no
Název v anglickém jazyce
The Role of Protein p16(INK4a) in Glottic Laryngeal Squamous Cell Carcinoma
Popis výsledku anglicky
Head and neck squamous cell cancer (HNSCC) includes tumors of various anatomical sites sharing the common etiological factors. However some differences in pathogenesis and prognosis of HNSCC have been hitherto documented. Laryngeal squamous cell carcinoma (LSCC) is one the most common type of the head and neck cancer. The majority of laryngeal cancers are located in the glottic area. P16 was recently documented to be important prognostic marker in many tumors including HNSCC. The aim of our study was toassess the significance of p16 expression in glottic LSCC. Fifty eight patients after surgical treatment of the glottic LSCC were enrolled in the retrospective study. The p16 expression was immunohistochemically detected and semiquantitatively evaluatedin tumor tissue. The results were statistically correlated with clinical and pathological parameters. Protein p16 was expressed in glottic LSCC of 15 patients (25.9 %). Statistically significant higher p16 overexpression was proven in no
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pathology Oncology Research
ISSN
1219-4956
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
HU - Maďarsko
Počet stran výsledku
7
Strana od-do
909-915
Kód UT WoS článku
000342554600019
EID výsledku v databázi Scopus
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