Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10282721" target="_blank" >RIV/00179906:_____/14:10282721 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10282721

Výsledek na webu

<a href="http://dx.doi.org/10.1515/cclm-2013-0162" target="_blank" >http://dx.doi.org/10.1515/cclm-2013-0162</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2013-0162" target="_blank" >10.1515/cclm-2013-0162</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium

Popis výsledku v původním jazyce

Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylationof GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma ofendometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions:In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of t

Název v anglickém jazyce

Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium

Popis výsledku anglicky

Background: Epigenetic changes are considered to be a frequent event during tumor development. Various methylation changes have been identified and show promise as potential cancer biomarkers. The aim of this study was to investigate promoter methylationof GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Methods: To search for promoter methylation of GATA4 and TP53 genes we used methylation-specific PCR (MSP) to compare the methylation status of 54 patients with endometrioid carcinoma ofendometrium and 18 patients with normal endometrial tissue. Results: In our study MSP revealed GATA4 promoter methylation in 44 of 54 in the carcinoma group (81.5%), and in none of the control group. No methylation was observed in TP53 gene. Conclusions:In conclusion, our study showed that there is significantly higher methylation in GATA4 gene in the endometrial cancer group compared with samples of nonneoplastic endometrium. The finding suggests the importance of hypermethylation of t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

1229-1234

Kód UT WoS článku

000340786100026

EID výsledku v databázi Scopus

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