HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10283810" target="_blank" >RIV/00179906:_____/14:10283810 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/14:43875352 RIV/00216208:11150/14:10283810

Výsledek na webu

<a href="http://www.nel.edu/archive_issues/o/35_s2/35_s2_Kunes_186-191.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/35_s2/35_s2_Kunes_186-191.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs

Popis výsledku v původním jazyce

Oxime HI-6 DMS (dimethanesulfonate) is an asymmetric bispyridinium aldoxime and essential acetylcholinesterase (AChE) reactivator. The high effectiveness is due to its wide spectrum of therapeutic activity against different structures of nerve agents. Aim of this study was to compare plasma time profiles and tissue distribution (to delimitation of potential toxicity risks) after its intramuscular (i.m.) and intragastric (i.g.) administration to experimental pigs. The study entered female Landrace pigs (Sus scrofa f. domestica), 4-5 months old animals, 29+-3.2 kg of body weight. Before the HI-6 DMS administration (i.m. injection or i.g. using a gastric tube), vena auricularis was cannulated (under general anaesthesia) for collection of blood samples. The tissue distribution study was carried out at expected t-max. Concentrations of HI-6 DMS in blood plasma and other tissue samples were detected by means of HPLC method. Fast absorption after i.m. administration, relatively slow absorptio

Název v anglickém jazyce

HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs

Popis výsledku anglicky

Oxime HI-6 DMS (dimethanesulfonate) is an asymmetric bispyridinium aldoxime and essential acetylcholinesterase (AChE) reactivator. The high effectiveness is due to its wide spectrum of therapeutic activity against different structures of nerve agents. Aim of this study was to compare plasma time profiles and tissue distribution (to delimitation of potential toxicity risks) after its intramuscular (i.m.) and intragastric (i.g.) administration to experimental pigs. The study entered female Landrace pigs (Sus scrofa f. domestica), 4-5 months old animals, 29+-3.2 kg of body weight. Before the HI-6 DMS administration (i.m. injection or i.g. using a gastric tube), vena auricularis was cannulated (under general anaesthesia) for collection of blood samples. The tissue distribution study was carried out at expected t-max. Concentrations of HI-6 DMS in blood plasma and other tissue samples were detected by means of HPLC method. Fast absorption after i.m. administration, relatively slow absorptio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/NT14270" target="_blank" >NT14270: Farmakokinetika a gastrointestinální motorické účinky nových acetylcholinesterasových modulátorů u experimentálních prasat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

Suppl. 2

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

6

Strana od-do

186-191

Kód UT WoS článku

000351064900025

EID výsledku v databázi Scopus

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