Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10290056" target="_blank" >RIV/00179906:_____/14:10290056 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10290056

Výsledek na webu

<a href="http://dx.doi.org/10.3233/CH-131668" target="_blank" >http://dx.doi.org/10.3233/CH-131668</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/CH-131668" target="_blank" >10.3233/CH-131668</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia

Popis výsledku v původním jazyce

INTRODUCTION: Impairment of the intestinal microcirculation in endotoxemia may cause a deterioration of the mucosal barrier function thus releasing intraluminal bacteria and their toxins into the systemic circulation. In clinical sepsis this mechanism may influence disease severity and outcome. The aim of the study was to investigate the impact of cannabinoid receptor 1 (CB1R) modulation within the intestinal microcirculation with regard to leukocyte activation and capillary perfusion, and on intestinalhistology in experimental endotoxemia in rats.CONCLUSIONS: CB1R inhibition significantly improved intestinal microcirculation by reducing leukocyte adhesion and increasing FCD in acute endotoxemia in rats. The data supports the involvement of the CB1R signaling in leukocyte activation during sepsis. Drugs targeting the CB1R may have therapeutic potential in systemic inflammation, such as sepsis.

Název v anglickém jazyce

Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia

Popis výsledku anglicky

INTRODUCTION: Impairment of the intestinal microcirculation in endotoxemia may cause a deterioration of the mucosal barrier function thus releasing intraluminal bacteria and their toxins into the systemic circulation. In clinical sepsis this mechanism may influence disease severity and outcome. The aim of the study was to investigate the impact of cannabinoid receptor 1 (CB1R) modulation within the intestinal microcirculation with regard to leukocyte activation and capillary perfusion, and on intestinalhistology in experimental endotoxemia in rats.CONCLUSIONS: CB1R inhibition significantly improved intestinal microcirculation by reducing leukocyte adhesion and increasing FCD in acute endotoxemia in rats. The data supports the involvement of the CB1R signaling in leukocyte activation during sepsis. Drugs targeting the CB1R may have therapeutic potential in systemic inflammation, such as sepsis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Hemorheology and Microcirculation

ISSN

1386-0291

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

333-342

Kód UT WoS článku

000346271800004

EID výsledku v databázi Scopus

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