POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10326817" target="_blank" >RIV/00179906:_____/16:10326817 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00089784 RIV/00216208:11150/16:10326817

Výsledek na webu

<a href="https://www.dovepress.com/pope-study-rationale-and-methodology-of-a-study-to-phenotype-patients--peer-reviewed-fulltext-article-COPD" target="_blank" >https://www.dovepress.com/pope-study-rationale-and-methodology-of-a-study-to-phenotype-patients--peer-reviewed-fulltext-article-COPD</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/COPD.S88846" target="_blank" >10.2147/COPD.S88846</a>

Jazyk výsledku

angličtina

Název v původním jazyce

POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe

Popis výsledku v původním jazyce

Chronic obstructive pulmonary disease (COPD) constitutes a major health challenge in Central and Eastern European (CEE) countries. However, clinical phenotypes, symptom load, and treatment habits of patients with COPD in CEE countries remain largely unknown. This paper provides a rationale for phenotyping COPD and describes the methodol-ogy of a large study in CEE. The POPE study is an international, multicenter, observational cross-sectional survey of patients with COPD in CEE. Participation in the study is offered to all consecutive outpatients with stable COPD in 84 centers across the CEE region if they fulfill the following criteria: age .40 years, smoking history $10 pack-years, a confirmed diagnosis of COPD with postbronchodilator FEV1/FVC ,0.7, and absence of COPD exacerbation $4 weeks. Medical history, risk factors for COPD, comorbidities, lung function parameters, symptoms, and phar-maceutical and nonpharmaceutical treatment are recorded. The POPE project is registered in ClinicalTrials.gov with the identifier NCT02119494. The primary aim of the POPE study was to phenotype patients with COPD in a real-life setting within CEE countries using predefined classifications. Secondary aims of the study included analysis of differences in symptoms, and diagnostic and therapeutic behavior in participating CEE countries. There is increasing acceptance toward a phenotype-driven therapeutic approach in COPD. The POPE study may contribute to reveal important information regarding phenotypes and therapy in real-life CEE.

Název v anglickém jazyce

POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe

Popis výsledku anglicky

Chronic obstructive pulmonary disease (COPD) constitutes a major health challenge in Central and Eastern European (CEE) countries. However, clinical phenotypes, symptom load, and treatment habits of patients with COPD in CEE countries remain largely unknown. This paper provides a rationale for phenotyping COPD and describes the methodol-ogy of a large study in CEE. The POPE study is an international, multicenter, observational cross-sectional survey of patients with COPD in CEE. Participation in the study is offered to all consecutive outpatients with stable COPD in 84 centers across the CEE region if they fulfill the following criteria: age .40 years, smoking history $10 pack-years, a confirmed diagnosis of COPD with postbronchodilator FEV1/FVC ,0.7, and absence of COPD exacerbation $4 weeks. Medical history, risk factors for COPD, comorbidities, lung function parameters, symptoms, and phar-maceutical and nonpharmaceutical treatment are recorded. The POPE project is registered in ClinicalTrials.gov with the identifier NCT02119494. The primary aim of the POPE study was to phenotype patients with COPD in a real-life setting within CEE countries using predefined classifications. Secondary aims of the study included analysis of differences in symptoms, and diagnostic and therapeutic behavior in participating CEE countries. There is increasing acceptance toward a phenotype-driven therapeutic approach in COPD. The POPE study may contribute to reveal important information regarding phenotypes and therapy in real-life CEE.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Chronic Obstructive Pulmonary Disease [online]

ISSN

1178-2005

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

2016

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

12

Strana od-do

611-622

Kód UT WoS článku

000372577600001

EID výsledku v databázi Scopus

2-s2.0-84961589420