Amniotic fluid calreticulin in pregnancies complicated by the preterm prelabor rupture of membranes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10332847" target="_blank" >RIV/00179906:_____/16:10332847 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/16:10332847 RIV/00843989:_____/16:E0105615

Výsledek na webu

<a href="http://dx.doi.org/10.3109/14767058.2016.1154940" target="_blank" >http://dx.doi.org/10.3109/14767058.2016.1154940</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/14767058.2016.1154940" target="_blank" >10.3109/14767058.2016.1154940</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Amniotic fluid calreticulin in pregnancies complicated by the preterm prelabor rupture of membranes

Popis výsledku v původním jazyce

Objective: This study aimed to determine the amniotic fluid calreticulin concentrations in women with the preterm prelabor rupture of membranes (PPROM) based on the microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI) and microbial-associated IAI.Methods: One hundred sixty-eight women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for calreticulin concentrations by ELISA. IAI was defined as an amniotic fluid interleukin-6 concentration>745pg/ml. Microbial-associated IAI was defined as the presence of both MIAC and IAI.Result: Women with MIAC (with MIAC: median 54.4ng/ml, versus without MIAC: median 32.6ng/ml; p<0.0001), IAI (with IAI: median 66.8ng/ml, versus without IAI: median 33.0ng/ml; p<0.0001) and microbial-associated IAI (with microbial-associated IAI: median 82.5ng/ml, versus without microbial-associated IAI: median 33.7ng/ml; p<0.0001) had higher concentrations of calreticulin than women without these complications. An amniotic fluid calreticulin concentration of 81.4ng/ml was found to be the best cutoff point for identifying women with microbial-associated IAI.Conclusions: The presence of microbial-associated IAI is associated with increased amniotic fluid calreticulin concentrations. Calreticulin seems to be a promising marker for the early identification of PPROM complicated by microbial-associated IAI.

Název v anglickém jazyce

Amniotic fluid calreticulin in pregnancies complicated by the preterm prelabor rupture of membranes

Popis výsledku anglicky

Objective: This study aimed to determine the amniotic fluid calreticulin concentrations in women with the preterm prelabor rupture of membranes (PPROM) based on the microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI) and microbial-associated IAI.Methods: One hundred sixty-eight women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for calreticulin concentrations by ELISA. IAI was defined as an amniotic fluid interleukin-6 concentration>745pg/ml. Microbial-associated IAI was defined as the presence of both MIAC and IAI.Result: Women with MIAC (with MIAC: median 54.4ng/ml, versus without MIAC: median 32.6ng/ml; p<0.0001), IAI (with IAI: median 66.8ng/ml, versus without IAI: median 33.0ng/ml; p<0.0001) and microbial-associated IAI (with microbial-associated IAI: median 82.5ng/ml, versus without microbial-associated IAI: median 33.7ng/ml; p<0.0001) had higher concentrations of calreticulin than women without these complications. An amniotic fluid calreticulin concentration of 81.4ng/ml was found to be the best cutoff point for identifying women with microbial-associated IAI.Conclusions: The presence of microbial-associated IAI is associated with increased amniotic fluid calreticulin concentrations. Calreticulin seems to be a promising marker for the early identification of PPROM complicated by microbial-associated IAI.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Maternal-Fetal &amp; Neonatal Medicine

ISSN

1476-7058

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

3921-3929

Kód UT WoS článku

000384680900001

EID výsledku v databázi Scopus

2-s2.0-84961211039