Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F17%3A10363738" target="_blank" >RIV/00179906:_____/17:10363738 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00044-017-1931-9" target="_blank" >http://dx.doi.org/10.1007/s00044-017-1931-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00044-017-1931-9" target="_blank" >10.1007/s00044-017-1931-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Popis výsledku v původním jazyce

In this study, a series of newly synthesized acridine derivatives, compounds 4, 6a, and 6b, are described and their biological activity on HL-60 cell lines is assessed using a number of different techniques. Binding studies were also performed between the derivatives and DNA in order to characterize the mechanism of the agents&apos; effect in more detail. The results of ultraviolet-visible absorption spectroscopy prove that the binding of derivatives 4, 6a, and 6b had occurred with a binding constant value of K = 3.5 x 104 -4.0 x 104 M-1. These findings are indicative of a strong interaction between the derivatives and DNA, and this hypothesis is supported by the results of the fluorescence emission, linear dichroism, and viscometric assays.

Název v anglickém jazyce

Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Popis výsledku anglicky

In this study, a series of newly synthesized acridine derivatives, compounds 4, 6a, and 6b, are described and their biological activity on HL-60 cell lines is assessed using a number of different techniques. Binding studies were also performed between the derivatives and DNA in order to characterize the mechanism of the agents&apos; effect in more detail. The results of ultraviolet-visible absorption spectroscopy prove that the binding of derivatives 4, 6a, and 6b had occurred with a binding constant value of K = 3.5 x 104 -4.0 x 104 M-1. These findings are indicative of a strong interaction between the derivatives and DNA, and this hypothesis is supported by the results of the fluorescence emission, linear dichroism, and viscometric assays.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicinal Chemistry Research

ISSN

1054-2523

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

2309-2321

Kód UT WoS článku

000412416600008

EID výsledku v databázi Scopus

2-s2.0-85020667695