Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F19%3A10402164" target="_blank" >RIV/00179906:_____/19:10402164 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/19:10402164

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JrpMzyjJc3" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JrpMzyjJc3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2019/5371381" target="_blank" >10.1155/2019/5371381</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study

Popis výsledku v původním jazyce

Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin &gt; 75 μmol/L, carbohydrate antigen 19-9 &gt; 400 U/mL) and the length of stenosis (&gt;15mm) can be helpful but are not specific enough. The aim of this study was to investigate bile acids in liver bile of patients with benign and malignant biliary stenosis and controls without stenosis. A total of 73 patients entered the study: 7 subjects with benign biliary stenosis (6 men, 1 woman; 68 +- 13 years old), 21 with malignant biliary stenosis (15 men, 6 women; 72 +- 14 years old), and 45 patients without biliary stenosis (22 men, 23 women; 70 +- 13 years old); out of those, 25 subjects have and 20 do not have choledocholithiasis. Twenty-three different bile acids were investigated by highperformance liquid chromatography/mass spectrometry. Serum total bilirubin was significantly higher in patients with malignant biliary stenosis compared with nonstenotic controls (p = 0:005). Significant relationship (r &gt; 0:7) was found between several pairs of bile acids. Significantly lower bile acid concentrations in malignant biliary stenosis compared to controls without stenosis were found for GLCA (p = 0:032), GUDCA (p = 0:032), GCDCA (p = 0:006), GDCA (p = 0:031), GHCA (p = 0:005), TUDCA (p = 0:044), and TDCA (p = 0:036). ignificant difference in cholic acid was found between benign and malignant stenosis (p = 0:022). Analysis of bile acids might be helpful in the differential diagnosis of malignant and benign biliary stenosis. More patients need to be enrolled in further studies so that the real diagnostic yield of bile acids can be determined.

Název v anglickém jazyce

Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study

Popis výsledku anglicky

Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin &gt; 75 μmol/L, carbohydrate antigen 19-9 &gt; 400 U/mL) and the length of stenosis (&gt;15mm) can be helpful but are not specific enough. The aim of this study was to investigate bile acids in liver bile of patients with benign and malignant biliary stenosis and controls without stenosis. A total of 73 patients entered the study: 7 subjects with benign biliary stenosis (6 men, 1 woman; 68 +- 13 years old), 21 with malignant biliary stenosis (15 men, 6 women; 72 +- 14 years old), and 45 patients without biliary stenosis (22 men, 23 women; 70 +- 13 years old); out of those, 25 subjects have and 20 do not have choledocholithiasis. Twenty-three different bile acids were investigated by highperformance liquid chromatography/mass spectrometry. Serum total bilirubin was significantly higher in patients with malignant biliary stenosis compared with nonstenotic controls (p = 0:005). Significant relationship (r &gt; 0:7) was found between several pairs of bile acids. Significantly lower bile acid concentrations in malignant biliary stenosis compared to controls without stenosis were found for GLCA (p = 0:032), GUDCA (p = 0:032), GCDCA (p = 0:006), GDCA (p = 0:031), GHCA (p = 0:005), TUDCA (p = 0:044), and TDCA (p = 0:036). ignificant difference in cholic acid was found between benign and malignant stenosis (p = 0:022). Analysis of bile acids might be helpful in the differential diagnosis of malignant and benign biliary stenosis. More patients need to be enrolled in further studies so that the real diagnostic yield of bile acids can be determined.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gastroenterology Research and Practice

ISSN

1687-6121

e-ISSN

—

Svazek periodika

2019

Číslo periodika v rámci svazku

Spec. Iss.

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

5371381

Kód UT WoS článku

000521586800001

EID výsledku v databázi Scopus

2-s2.0-85077430903