Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F19%3A10408187" target="_blank" >RIV/00179906:_____/19:10408187 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XrPy3iFkbE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XrPy3iFkbE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/ehz620" target="_blank" >10.1093/eurheartj/ehz620</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

Popis výsledku v původním jazyce

AimsThe EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE).Methodsand resultsProspective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hos-pitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnosticcriteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan,18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were col-lected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), anddevice-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients.Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), entero-cocci in 390 (15.8%), andStreptococcus gallolyticusin 162 (6.6%).18F-fluorodeoxyglucose positron emission tomog-raphy/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (majorcriterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE(16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid orpulmonary IE, presence of a vegetation andStaphylococcus aureusIE. According to ESC guidelines, cardiac surgerywas indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital deathoccurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality wereCharlson index, creatinine &gt; 2 mg/dL, congestive heart failure, vegetation length &gt; 10 mm, cerebral complications,abscess, and failure to undertake surgery when indicated.ConclusionInfective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in itsclinical, microbiological, imaging, and therapeutic profilesKeywordsInfective endocarditis.

Název v anglickém jazyce

Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

Popis výsledku anglicky

AimsThe EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE).Methodsand resultsProspective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hos-pitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnosticcriteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan,18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were col-lected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), anddevice-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients.Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), entero-cocci in 390 (15.8%), andStreptococcus gallolyticusin 162 (6.6%).18F-fluorodeoxyglucose positron emission tomog-raphy/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (majorcriterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE(16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid orpulmonary IE, presence of a vegetation andStaphylococcus aureusIE. According to ESC guidelines, cardiac surgerywas indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital deathoccurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality wereCharlson index, creatinine &gt; 2 mg/dL, congestive heart failure, vegetation length &gt; 10 mm, cerebral complications,abscess, and failure to undertake surgery when indicated.ConclusionInfective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in itsclinical, microbiological, imaging, and therapeutic profilesKeywordsInfective endocarditis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Heart Journal

ISSN

0195-668X

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

39

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

3222-3232

Kód UT WoS článku

000491247400007

EID výsledku v databázi Scopus

2-s2.0-85073182903