Outcomes of Mechanical Thrombectomy of Acute Basilar Artery Occlusion Due to Underlying Intracranial Atherosclerotic Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10455447" target="_blank" >RIV/00179906:_____/23:10455447 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qBWlvDg.mj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qBWlvDg.mj</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/SVIN.122.000429" target="_blank" >10.1161/SVIN.122.000429</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Outcomes of Mechanical Thrombectomy of Acute Basilar Artery Occlusion Due to Underlying Intracranial Atherosclerotic Disease

Popis výsledku v původním jazyce

Background: Intracranial atherosclerotic disease (ICAD) is a common cause of posterior circulation acute ischemic stroke. We aimed to compare baseline characteristics, recanalization rates, and clinical outcomes in patients with acute basilar occlusion due to underlying ICAD to patients with other causes of occlusion. Methods: The Trevo Registry (ClinicalTrials.gov Identifier: NCT02040259) was a prospective open-label mechanical thrombectomy registry that included 2008 patients from 76 sites across 12 countries. For a secondary analysis, we selected patients with isolated acute basilar occlusion. We then classified patients into 2 groups: patients with acute basilar artery occlusion due to ICAD (ICAD group) and patients with acute basilar occlusion due to another cause (non-ICAD group). Results: We identified 90 subjects with acute basilar occlusion. According to stroke mechanism, there were 9 (10.0%) patients in the ICAD group and 81 (90.0%) in the non-ICAD group. There was a significant difference (P=0.001) in the lesion location between the 2 groups, with 60.5% of non-ICAD occlusions located in the distal region and no ICAD occlusions there. The 2 groups showed a significant difference (P=0.003) for rescue therapy with balloon angioplasty, with 33.3% in the ICAD group and 1.2% in the non-ICAD group, respectively. In a multivariable model adjusted for age, baseline National Institutes of Health Stroke Scale, and intravenous tissue-type plasminogen activator (tPA), the odds of 90-day death (odds ratio=4.6; P=0.10) were higher for atherosclerotic subjects. Conclusion: Acute basilar occlusions related to ICAD showed a similar good clinical outcome (modified Rankin scale (mRS) 0-2) and a tendency for a higher rate of 90-day mortality compared with non-ICAD occlusions.

Název v anglickém jazyce

Outcomes of Mechanical Thrombectomy of Acute Basilar Artery Occlusion Due to Underlying Intracranial Atherosclerotic Disease

Popis výsledku anglicky

Background: Intracranial atherosclerotic disease (ICAD) is a common cause of posterior circulation acute ischemic stroke. We aimed to compare baseline characteristics, recanalization rates, and clinical outcomes in patients with acute basilar occlusion due to underlying ICAD to patients with other causes of occlusion. Methods: The Trevo Registry (ClinicalTrials.gov Identifier: NCT02040259) was a prospective open-label mechanical thrombectomy registry that included 2008 patients from 76 sites across 12 countries. For a secondary analysis, we selected patients with isolated acute basilar occlusion. We then classified patients into 2 groups: patients with acute basilar artery occlusion due to ICAD (ICAD group) and patients with acute basilar occlusion due to another cause (non-ICAD group). Results: We identified 90 subjects with acute basilar occlusion. According to stroke mechanism, there were 9 (10.0%) patients in the ICAD group and 81 (90.0%) in the non-ICAD group. There was a significant difference (P=0.001) in the lesion location between the 2 groups, with 60.5% of non-ICAD occlusions located in the distal region and no ICAD occlusions there. The 2 groups showed a significant difference (P=0.003) for rescue therapy with balloon angioplasty, with 33.3% in the ICAD group and 1.2% in the non-ICAD group, respectively. In a multivariable model adjusted for age, baseline National Institutes of Health Stroke Scale, and intravenous tissue-type plasminogen activator (tPA), the odds of 90-day death (odds ratio=4.6; P=0.10) were higher for atherosclerotic subjects. Conclusion: Acute basilar occlusions related to ICAD showed a similar good clinical outcome (modified Rankin scale (mRS) 0-2) and a tendency for a higher rate of 90-day mortality compared with non-ICAD occlusions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stroke: Vascular and Interventional Neurology

ISSN

2694-5746

e-ISSN

2694-5746

Svazek periodika

3

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

e000429

Kód UT WoS článku

001151798300005

EID výsledku v databázi Scopus

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