Mucosal healing is not associated with better outcome during 7 years of follow-up in pediatric patients with Crohn's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10442427" target="_blank" >RIV/00179906:_____/24:10442427 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/24:10442427

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hgXl1WVpL7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hgXl1WVpL7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S2724-5276.21.06099-0" target="_blank" >10.23736/S2724-5276.21.06099-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mucosal healing is not associated with better outcome during 7 years of follow-up in pediatric patients with Crohn's disease

Popis výsledku v původním jazyce

Background: Mucosal healing (MH) has become a perspective treatment target in patients with Crohn&apos;s disease (CD). Data about the impact of MH on long-term outcome in pediatric patients are still scarce. Methods: 76 pediatric patients with CD were evaluated retrospectively (2000-2015) in a tertiary care center. Based on MH achievement, they were divided into two groups (MH, n= 17; and No MH, n=59). The primary endpoint was to assess the association of MH and the need for CD-related hospitalizations or surgery in pediatric patients with CD. Results: The number of hospitalized patients was 24% in the MH group and 42% in the No MH group, P = 0.26. The total number of CD-related hospitalizations was not significant between the MH group and the No MH group (5 vs. 41, P = 0.15). The time to the first hospitalization was 24 months in MH and 21 months in No MH, P&gt;0.99. 24% patients in the MH group and 39% patients in the No MH group underwent CD-related operation, P = 0.39. Time to the first operation was 43 months for MH and 19 months for the No MH group, P = 0.13. The follow-up period was 91 months in the MH group and 80 months in the No MH group, P = 0.74. The use of infliximab was positively associated with MH, P = 0.002. Conclusions: MH was not associated with fewer CD-related hospitalizations or operations in pediatric patients with CD during seven years of follow-up.

Název v anglickém jazyce

Mucosal healing is not associated with better outcome during 7 years of follow-up in pediatric patients with Crohn's disease

Popis výsledku anglicky

Background: Mucosal healing (MH) has become a perspective treatment target in patients with Crohn&apos;s disease (CD). Data about the impact of MH on long-term outcome in pediatric patients are still scarce. Methods: 76 pediatric patients with CD were evaluated retrospectively (2000-2015) in a tertiary care center. Based on MH achievement, they were divided into two groups (MH, n= 17; and No MH, n=59). The primary endpoint was to assess the association of MH and the need for CD-related hospitalizations or surgery in pediatric patients with CD. Results: The number of hospitalized patients was 24% in the MH group and 42% in the No MH group, P = 0.26. The total number of CD-related hospitalizations was not significant between the MH group and the No MH group (5 vs. 41, P = 0.15). The time to the first hospitalization was 24 months in MH and 21 months in No MH, P&gt;0.99. 24% patients in the MH group and 39% patients in the No MH group underwent CD-related operation, P = 0.39. Time to the first operation was 43 months for MH and 19 months for the No MH group, P = 0.13. The follow-up period was 91 months in the MH group and 80 months in the No MH group, P = 0.74. The use of infliximab was positively associated with MH, P = 0.002. Conclusions: MH was not associated with fewer CD-related hospitalizations or operations in pediatric patients with CD during seven years of follow-up.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Minerva Pediatrics

ISSN

2724-5276

e-ISSN

2724-5780

Svazek periodika

76

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

381-387

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85195435814