Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10481215" target="_blank" >RIV/00179906:_____/24:10481215 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18470/24:50020874

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GziUgK25V1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GziUgK25V1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jff.2023.105915" target="_blank" >10.1016/j.jff.2023.105915</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies

Popis výsledku v původním jazyce

The effects of the gut microbiome on the brain and the mechanisms of gut-brain communication have been popular research topics for the past few decades. The term gut-brain axis (GBA) evolved to illustrate how the gut and gut microbiota communicate with the brain. The gut-brain axis is an interplay of the neural, endocrine, immune, and metabolic pathways that help to maintain the brain&apos;s homeostasis. Several groups have reported that gut dysbiosis is significantly associated with neuroinflammation, aggregation of amyloid beta, and an increase in oxidative stress during Alzheimer&apos;s disease (AD). Understanding the exact mechanism of how the gut microbiome influences brain function may help develop new therapeutic modalities for AD. This review highlights the functioning of the gut microbiome in AD pathogenesis, the potential beneficial effects of probiotic exopolysaccharides as therapeutic molecules, and the potential benefits of probiotic exopolysaccharides (EPS) as a ray of hope in treating AD.

Název v anglickém jazyce

Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies

Popis výsledku anglicky

The effects of the gut microbiome on the brain and the mechanisms of gut-brain communication have been popular research topics for the past few decades. The term gut-brain axis (GBA) evolved to illustrate how the gut and gut microbiota communicate with the brain. The gut-brain axis is an interplay of the neural, endocrine, immune, and metabolic pathways that help to maintain the brain&apos;s homeostasis. Several groups have reported that gut dysbiosis is significantly associated with neuroinflammation, aggregation of amyloid beta, and an increase in oxidative stress during Alzheimer&apos;s disease (AD). Understanding the exact mechanism of how the gut microbiome influences brain function may help develop new therapeutic modalities for AD. This review highlights the functioning of the gut microbiome in AD pathogenesis, the potential beneficial effects of probiotic exopolysaccharides as therapeutic molecules, and the potential benefits of probiotic exopolysaccharides (EPS) as a ray of hope in treating AD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Functional Foods

ISSN

1756-4646

e-ISSN

2214-9414

Svazek periodika

112

Číslo periodika v rámci svazku

JAN

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

105915

Kód UT WoS článku

001128425100001

EID výsledku v databázi Scopus

2-s2.0-85178437767