A comprehensive study on the degradation process of medical-grade polydioxanone at low pH

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10483900" target="_blank" >RIV/00179906:_____/24:10483900 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18470/24:50021665 RIV/00216208:11150/24:10483900 RIV/00216275:25310/24:39922013

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=473L7HOLih" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=473L7HOLih</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.polymertesting.2024.108536" target="_blank" >10.1016/j.polymertesting.2024.108536</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A comprehensive study on the degradation process of medical-grade polydioxanone at low pH

Popis výsledku v původním jazyce

Polydioxanone (PPDX) has gained significant attention as a biocompatible and absorbable polymer used various medical applications, such as sutures and tissue scaffolds. This research presents a thorough investigation into the degradation mechanisms of PPDX under low pH conditions, simulating physiological environments, e.g., esophagus and stomach. It mainly focuses on the dependence of the PPDX degradation rate on various ambient pH values (7.4 and below), which is a substantial knowledge for successful gastrointestinal treatment. The PPDX suture samples were degraded for up to 6 weeks and analyzed using size exclusion chromatography, differential scanning calorimetry, Raman spectroscopy, scanning electron microscopy, X-ray microtomography, and mechanical property measurements. The results show that the PPDX degradation is significantly accelerated at pH below 1.67. Correlations of the molecular weight, crystallinity, glass transition temperature, Young&apos;s modulus, shear modulus, tensile strength, and the 1733 cm-- 1 Raman peak shoulder area (RPSA1733) indicate that the degradation mechanism does not change with increasing acidity. Measurements of tensile strength, shear modulus, and RPSA1733 were found to be the most suitable parameters for characterizing the PPDX filament&apos;s macroscopic integrity. Raman spectroscopy is of particular interest in this regard due to its rapidity and practically no requirements on the sample preparation.

Název v anglickém jazyce

A comprehensive study on the degradation process of medical-grade polydioxanone at low pH

Popis výsledku anglicky

Polydioxanone (PPDX) has gained significant attention as a biocompatible and absorbable polymer used various medical applications, such as sutures and tissue scaffolds. This research presents a thorough investigation into the degradation mechanisms of PPDX under low pH conditions, simulating physiological environments, e.g., esophagus and stomach. It mainly focuses on the dependence of the PPDX degradation rate on various ambient pH values (7.4 and below), which is a substantial knowledge for successful gastrointestinal treatment. The PPDX suture samples were degraded for up to 6 weeks and analyzed using size exclusion chromatography, differential scanning calorimetry, Raman spectroscopy, scanning electron microscopy, X-ray microtomography, and mechanical property measurements. The results show that the PPDX degradation is significantly accelerated at pH below 1.67. Correlations of the molecular weight, crystallinity, glass transition temperature, Young&apos;s modulus, shear modulus, tensile strength, and the 1733 cm-- 1 Raman peak shoulder area (RPSA1733) indicate that the degradation mechanism does not change with increasing acidity. Measurements of tensile strength, shear modulus, and RPSA1733 were found to be the most suitable parameters for characterizing the PPDX filament&apos;s macroscopic integrity. Raman spectroscopy is of particular interest in this regard due to its rapidity and practically no requirements on the sample preparation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymer Testing

ISSN

0142-9418

e-ISSN

1873-2348

Svazek periodika

138

Číslo periodika v rámci svazku

SEP

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

20

Strana od-do

108536

Kód UT WoS článku

001293426400001

EID výsledku v databázi Scopus

2-s2.0-85200816288