Epidemiology, etiopathogenesis, and management of MRONJ: A European multicenter study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10489222" target="_blank" >RIV/00179906:_____/24:10489222 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/24:10489222

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TfE9_ddXmY" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TfE9_ddXmY</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jormas.2024.101931" target="_blank" >10.1016/j.jormas.2024.101931</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Epidemiology, etiopathogenesis, and management of MRONJ: A European multicenter study

Popis výsledku v původním jazyce

Introduction: The purpose of this European multicenter study was to describe the general characteristics and risk factors of MRONJ lesions as well as their clinical diagnosis and management at different European Oral and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the epidemiology, etiopathogenesis, and the current trends in the treatment of MRONJ across Europe. Materials and methods: The following data were registered for each patient: gender; age at MRONJ diagnosis; past medical history; indication for antiresorptive or antiangiogenic therapy; type of antiresorptive medication; local risk factor for MRONJ; MRONJ Stage; anatomic location and symptoms; treatment; surgical complications; recurrence. Results: A total of 537 patients (375 females, 162 males) with MRONJ were included. Statistically significant associations were found between patients with metastatic bone disease and recurrences (P &lt; 0.0005) and between advanced MRONJ stages (stages 2 and 3) and recurrences (P &lt; 0.005). Statistically significant associations were also found between male gender and recurrences (P &lt; 0.05), and between MRONJ maxillary sites and recurrences (P &lt; 0.0000005). Conclusions: A longer mean duration of antiresorptive medications before MRONJ onset was observed in patients affected by osteoporosis, whereas a shorter mean duration was observed in all metastatic bone cancer patients, and in particular in those affected by prostate cancer with bone metastases or multiple myeloma. Surgery plays an important role for the management of MRONJ lesions. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, Al training, and similar technologies.

Název v anglickém jazyce

Epidemiology, etiopathogenesis, and management of MRONJ: A European multicenter study

Popis výsledku anglicky

Introduction: The purpose of this European multicenter study was to describe the general characteristics and risk factors of MRONJ lesions as well as their clinical diagnosis and management at different European Oral and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the epidemiology, etiopathogenesis, and the current trends in the treatment of MRONJ across Europe. Materials and methods: The following data were registered for each patient: gender; age at MRONJ diagnosis; past medical history; indication for antiresorptive or antiangiogenic therapy; type of antiresorptive medication; local risk factor for MRONJ; MRONJ Stage; anatomic location and symptoms; treatment; surgical complications; recurrence. Results: A total of 537 patients (375 females, 162 males) with MRONJ were included. Statistically significant associations were found between patients with metastatic bone disease and recurrences (P &lt; 0.0005) and between advanced MRONJ stages (stages 2 and 3) and recurrences (P &lt; 0.005). Statistically significant associations were also found between male gender and recurrences (P &lt; 0.05), and between MRONJ maxillary sites and recurrences (P &lt; 0.0000005). Conclusions: A longer mean duration of antiresorptive medications before MRONJ onset was observed in patients affected by osteoporosis, whereas a shorter mean duration was observed in all metastatic bone cancer patients, and in particular in those affected by prostate cancer with bone metastases or multiple myeloma. Surgery plays an important role for the management of MRONJ lesions. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, Al training, and similar technologies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Stomatology, Oral and Maxillofacial Surgery

ISSN

2468-8509

e-ISSN

2468-7855

Svazek periodika

125

Číslo periodika v rámci svazku

5(Suppl. 1)

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

7

Strana od-do

101931

Kód UT WoS článku

001325520800026

EID výsledku v databázi Scopus

2-s2.0-85195308392