Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10492746" target="_blank" >RIV/00179906:_____/25:10492746 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143849 RIV/00216208:11130/25:10492746 RIV/00216208:11150/25:10492746 RIV/00159816:_____/25:00082574 a 2 dalších

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KjbaqHcHu7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KjbaqHcHu7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5853/jos.2024.04077" target="_blank" >10.5853/jos.2024.04077</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment

Popis výsledku v původním jazyce

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with an increased risk of cerebrovascular and other thrombotic events. Previous studies have shown that patients with acute ischemic stroke (AIS) and coronavirus disease 2019 (COVID-19) have a worse functional outcome than those without concomitant SARS-CoV-2 infection. In patients receiving acute revascularization treatments, our large retrospective analysis of the Global COVID-19 Stroke Registry revealed higher rates of intracranial bleeding and worse clinical outcomes in patients with AIS and COVID-19 compared to contemporary AIS controls without COVID-19. Subsequent sub-analyses emphasized the impact of SARS-CoV-2 infection in this subgroup of patients showing differences in outcome between patients with asymptomatic COVID-19 and controls without COVID-19. We aimed to assess recanalization outcomes and procedural complication rates in patients with AIS and COVID-19 undergoing EVT in an international cohort by comparing them with a contemporary control group of non-COVID-19 patients from the same centers.We conducted a secondary analysis on the Global COVID-19 Stroke Registry. Inclusion and exclusion criteria for the Global COVID-19 Stroke Registry were previously described. For this study, only patients receiving EVT for intracranial occlusions were included (Supplementary Figure 1). Our analysis has several strengths, including the large sample size from 30 countries across five continents, increasing the validity and generalizability of our results.Limitations of our study include the retrospective design, non-blinded assessment, and absence of centralized imaging review, which may have influenced our results. The use of different thrombectomy equipment and techniques by stroke interventionists may have affected our results but were tentatively addressed by adjustment with a center cluster level variable. A significant number of centers did not report safety outcomes in control patients, which could have biased our results.In conclusion, in this cohort study, patients with AIS and COVID-19 receiving EVT had lower rates of recanalization and a higher risk of arterial perforation and reocclusion, in comparison with contemporary AIS controls without COVID-19. These findings may contribute to the poorer outcome found in patients with AIS and COVID-19.

Název v anglickém jazyce

Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment

Popis výsledku anglicky

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with an increased risk of cerebrovascular and other thrombotic events. Previous studies have shown that patients with acute ischemic stroke (AIS) and coronavirus disease 2019 (COVID-19) have a worse functional outcome than those without concomitant SARS-CoV-2 infection. In patients receiving acute revascularization treatments, our large retrospective analysis of the Global COVID-19 Stroke Registry revealed higher rates of intracranial bleeding and worse clinical outcomes in patients with AIS and COVID-19 compared to contemporary AIS controls without COVID-19. Subsequent sub-analyses emphasized the impact of SARS-CoV-2 infection in this subgroup of patients showing differences in outcome between patients with asymptomatic COVID-19 and controls without COVID-19. We aimed to assess recanalization outcomes and procedural complication rates in patients with AIS and COVID-19 undergoing EVT in an international cohort by comparing them with a contemporary control group of non-COVID-19 patients from the same centers.We conducted a secondary analysis on the Global COVID-19 Stroke Registry. Inclusion and exclusion criteria for the Global COVID-19 Stroke Registry were previously described. For this study, only patients receiving EVT for intracranial occlusions were included (Supplementary Figure 1). Our analysis has several strengths, including the large sample size from 30 countries across five continents, increasing the validity and generalizability of our results.Limitations of our study include the retrospective design, non-blinded assessment, and absence of centralized imaging review, which may have influenced our results. The use of different thrombectomy equipment and techniques by stroke interventionists may have affected our results but were tentatively addressed by adjustment with a center cluster level variable. A significant number of centers did not report safety outcomes in control patients, which could have biased our results.In conclusion, in this cohort study, patients with AIS and COVID-19 receiving EVT had lower rates of recanalization and a higher risk of arterial perforation and reocclusion, in comparison with contemporary AIS controls without COVID-19. These findings may contribute to the poorer outcome found in patients with AIS and COVID-19.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Stroke

ISSN

2287-6391

e-ISSN

2287-6405

Svazek periodika

27

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

KR - Korejská republika

Počet stran výsledku

5

Strana od-do

128-132

Kód UT WoS článku

001458705600001

EID výsledku v databázi Scopus

2-s2.0-85218168254