Urinary kynurenine, tryptophan, and neopterin concentrations during physiological pregnancy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10498801" target="_blank" >RIV/00179906:_____/25:10498801 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/25:10498801 RIV/61989592:15110/25:73631312 RIV/00098892:_____/25:10159283

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-2LXWkH8x1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-2LXWkH8x1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-04642-9" target="_blank" >10.1038/s41598-025-04642-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Urinary kynurenine, tryptophan, and neopterin concentrations during physiological pregnancy

Popis výsledku v původním jazyce

During pregnancy the alterations of kynurenine and tryptophan metabolism play an important role in local signalling and the prevention of fetal rejection. The aim was to investigate urinary levels of kynurenine and tryptophan during physiological pregnancy, and to determine their stability in urine during sample storage at different conditions. Urinary samples were obtained from 73 healthy pregnant women (median age 31 years), during the 1st, 2nd, and 3rd trimesters and from 42 healthy non-pregnant women (median age 30 years). Liquid chromatography methods using selective and sensitive mass spectrometry detection were used for analysis. Urinary neopterin, kynurenine, and tryptophan increased during the pregnancy and in comparison to the non-pregnant women. No correlation of the analytes with gestation age within each trimester and among the different analytes was observed. Kynurenine and tryptophan were stable in urine for 14 days at 4 degrees C, 6 months at -22 degrees C, and 12 months at -84 degrees C. Present results demonstrate differences in urinary concentrations of kynurenine, tryptophan, and neopterin between women with physiological pregnancy and healthy women. Simultaneous determination of kynurenine, tryptophan and neopterin may be explored in the disorders of pregnancy in future investigations.

Název v anglickém jazyce

Urinary kynurenine, tryptophan, and neopterin concentrations during physiological pregnancy

Popis výsledku anglicky

During pregnancy the alterations of kynurenine and tryptophan metabolism play an important role in local signalling and the prevention of fetal rejection. The aim was to investigate urinary levels of kynurenine and tryptophan during physiological pregnancy, and to determine their stability in urine during sample storage at different conditions. Urinary samples were obtained from 73 healthy pregnant women (median age 31 years), during the 1st, 2nd, and 3rd trimesters and from 42 healthy non-pregnant women (median age 30 years). Liquid chromatography methods using selective and sensitive mass spectrometry detection were used for analysis. Urinary neopterin, kynurenine, and tryptophan increased during the pregnancy and in comparison to the non-pregnant women. No correlation of the analytes with gestation age within each trimester and among the different analytes was observed. Kynurenine and tryptophan were stable in urine for 14 days at 4 degrees C, 6 months at -22 degrees C, and 12 months at -84 degrees C. Present results demonstrate differences in urinary concentrations of kynurenine, tryptophan, and neopterin between women with physiological pregnancy and healthy women. Simultaneous determination of kynurenine, tryptophan and neopterin may be explored in the disorders of pregnancy in future investigations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30100 - Basic medicine

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

19674

Kód UT WoS článku

001503073900013

EID výsledku v databázi Scopus

2-s2.0-105007248433