Plasma transfusions in neonatal intensive care units: a prospective observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10499879" target="_blank" >RIV/00179906:_____/25:10499879 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vv7sosaxum" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vv7sosaxum</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/archdischild-2024-327926" target="_blank" >10.1136/archdischild-2024-327926</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma transfusions in neonatal intensive care units: a prospective observational study

Popis výsledku v původním jazyce

Objective Despite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe.Design Prospective observational study.Setting 64 NICUs in 22 European countries, with a 6-week study period per centre between September 2022 and August 2023.Patients Preterm infants born below 32 weeks of gestational age.Interventions Admission to the NICU.Main outcome measures Plasma transfusion prevalence, cumulative incidence, indications, transfusion volumes and infusion rates and adverse effects.Results A total of 92 of 1143 infants included (8.0%) received plasma during the study period, collectively receiving 177 transfusions. Overall prevalence was 0.3 plasma transfusion days per 100 admission days, and rates varied substantially across Europe. By day 28 of life, 13.5% (95% CI 10.0% to 16.9%) of infants received at least one plasma transfusion, accounted for competing risks of death or discharge. Transfusions were given for a broad range of indications, including active bleeding (29.4%), abnormal coagulation screen results (23.7%) and volume replacement/hypotension (21.5%). Transfusion volumes and infusion rates varied significantly; the most common volume was 15 mL/kg (range: 5-30 mL/kg) and the most common duration was 2 hours (range: 30 min to 6 hours).Conclusions We found wide variation in plasma transfusion practices in Europe, highlighting the need for evidence to inform neonatologists in daily practice and guidelines, in particular for non-bleeding indications.Trial registration number ISRCTN17267090.

Název v anglickém jazyce

Plasma transfusions in neonatal intensive care units: a prospective observational study

Popis výsledku anglicky

Objective Despite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe.Design Prospective observational study.Setting 64 NICUs in 22 European countries, with a 6-week study period per centre between September 2022 and August 2023.Patients Preterm infants born below 32 weeks of gestational age.Interventions Admission to the NICU.Main outcome measures Plasma transfusion prevalence, cumulative incidence, indications, transfusion volumes and infusion rates and adverse effects.Results A total of 92 of 1143 infants included (8.0%) received plasma during the study period, collectively receiving 177 transfusions. Overall prevalence was 0.3 plasma transfusion days per 100 admission days, and rates varied substantially across Europe. By day 28 of life, 13.5% (95% CI 10.0% to 16.9%) of infants received at least one plasma transfusion, accounted for competing risks of death or discharge. Transfusions were given for a broad range of indications, including active bleeding (29.4%), abnormal coagulation screen results (23.7%) and volume replacement/hypotension (21.5%). Transfusion volumes and infusion rates varied significantly; the most common volume was 15 mL/kg (range: 5-30 mL/kg) and the most common duration was 2 hours (range: 30 min to 6 hours).Conclusions We found wide variation in plasma transfusion practices in Europe, highlighting the need for evidence to inform neonatologists in daily practice and guidelines, in particular for non-bleeding indications.Trial registration number ISRCTN17267090.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30200 - Clinical medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Disease in Childhood: Fetal and Neonatal Edition

ISSN

1359-2998

e-ISSN

1468-2052

Svazek periodika

110

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

452-459

Kód UT WoS článku

001407134100001

EID výsledku v databázi Scopus

2-s2.0-85216079362